Oxidative stress is one of the important mechanisms involved in Dexamethasone (Dex)-induced hypertension. Protocatechuic acid (PCA) is a natural compound with high antioxidant capacity. In this investigation, the effect of pretreatment with PCA was studied in Dex-induced hypertensive male Wistar rats. For induction of hypertension, Dex was injected subcutaneously for 14 days. PCA (50, 100 and 2...

Ginsenoside Rh1 is able to upregulate glucocorticoid receptor (GR) level, suggesting Rh1 may improve glucocorticoid efficacy in hormone-dependent diseases. Therefore, we investigated whether Rh1 could enhance the effect of dexamethasone (Dex) in the treatment of MRL/lpr mice. MRL/lpr mice were treated with vehicle, Dex, Rh1, or Dex + Rh1 for 4 weeks. Dex significantly reduced the proteinuria an...

Data-driven revision of decision models is defined as follows: given an existing model and a set of data items, revise the model to match the data items. In this paper, we propose and experimentally evaluate a method for the revision of qualitative hierarchical multi-attribute models in DEX methodology. The revision method is automatic, but limited to the modification of utility functions. Usin...

With this work, we demonstrate SALUS Patient History Tool which presents patient summaries to the clinical researcher by retrieving the values of the patient data fields from the semantic instances which come in the form of SALUS Common Information Model. The tool makes use of the SALUS Common Data Elements to extract the corresponding data from the semantic instance before presenting to the re...

Dexamethasone (DEX) suppresses the secretion of and responsiveness to growth hormone (GH). Here we aimed to assess the therapeutic effects of GH on the DEX-induced osteopenia. Female Wistar rats were treated for 2 weeks with DEX (200 microg/day) or saline as a control. DEX significantly decreased body weight gain, bone mineral density (BMD), growth plate thickness, area ratio of trabecular bone...

It has been demonstrated that dexmedetomidine (Dex) can protect patients with acute kidney injury from experiencing further tissue damage, however its mechanism of action remains unclear. The present study investigated the immune modulatory functions of Dex in rats with acute kidney injury (AKI) induced via injection of lipopolysaccharide into the tail vein. ELISA analysis showed that Dex reduc...

otostegia persica (burm.) boiss. is used for the treatment of various diseases in traditional medicine. the aim of this study was to assess the effects of hydroalcoholic extract of the aerial parts of o. persica in dexamethasone (dex) induced hypertension in male wistar rats. for induction of hypertension, dex at 30 µg/kg/day was administered subcutaneously for 14 days. in a prevention study, a...

Dexamethasone (DEX) is a potent immunosuppressive agent used in the treatment of several disorders. However, despite its beneficial effects, DEX puts patients at risk for opportunistic infections, especially pulmonary aspergillosis. Previously we reported that in vitro granulocyte-macrophage colony-stimulating factor (GM-CSF) blocks the immunosuppressive action of DEX on bronchoalveolar macroph...

We have previously shown that in vitro sensitivity to dexamethasone (DEX) stimulation in human endothelial cells is positively regulated by the glucocorticoid receptor (NR3C1, GR). The present study determined the role of differential GR transcriptional regulation in glucocorticoid sensitivity. We studied 25 human umbilical vein endothelial cells (HUVECs) that had been previously characterized ...