Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. We previously showed that Perilipin 2 (Plin2), a member of lipid droplet protein family, is markedly increased in fatty liver, and its reduction in the liver of diet-induced obese mice by antisense oligonucleotide (ASO) decreased steatosis and enhanced insulin sensitivity. Plin2-ASO treatment markedly suppresse...

Usher syndrome, Type 1C (USH1C) is an autosomal recessive inherited disorder in which a mutation in the gene encoding harmonin is associated with multi-sensory deficits (i.e., auditory, vestibular, and visual). USH1C (Usher) mice, engineered with a human USH1C mutation, exhibit these multi-sensory deficits by circling behavior and lack of response to sound. Administration of an antisense oligon...

BACKGROUND Neo-aortic root dilation (ARD) and neo-aortic regurgitation (AR) may be progressive after arterial switch operation (ASO) for d-loop transposition of the great arteries (dTGA). We sought to identify predictors of ARD and AR after ASO. METHODS AND RESULTS 335 patients were identified who underwent ASO for dTGA with intact ventricular septum or ventricular septal defect (VSD), includ...

Arteriosclerosis Obliteran (ASO) is a local manifestation of systemic arteriosclerosis in the lower extremity arteries. ASO chronic progressive disease caused by arteriosclerosis, such as intimal thickening, lumen stenosis or occlusion blood supply arteries limbs, insufficient diseased and clinical manifestations intermittent claudication, decreased skin temperature, pain, even ulceration necro...

Background Banding of the pulmonary artery to induce left ventricular (LV) hypertrophy followed by arterial switch operation (ASO) within 2 weeks has been performed when a primary ASO was considered high risk because of inadequate LV hypertrophy. Methods and Results Potential adverse myocardial effects of the two-stage procedure were examined by comparing outcome in 18 patients after a rapid tw...

The title compound, silver disodium trimolybdenum(VI) nonaoxide arsenate, AgNa(2)Mo(3)O(9)AsO(4), was prepared by a solid-state reaction at 808 K. The structure consists of an infinite (Mo(3)AsO(13))(n) ribbon, parallel to the c axis, composed of AsO(4) tetra-hedra and MoO(6) octa-hedra sharing edges and corners. The Na and Ag ions partially occupy several independent close positions, with vari...

Results A total of 163 ASO procedures of all types were identified. The diagnoses were; TGA/IVA 88, TGA/VSD 53, TGA/ arch 5, TGA/VSD/arch 4, Taussig Bing 10, Taussig Bing/ arch 9, for a total of 169, ten patients underwent a staged repair in preparation for ASO of which 4 died. One died before intervention, one did not undergo ASO operation at our institution. Total mortality for all ASO proced...

Arterial switch operation (ASO) is a complex neonatal in which transfer of the coronary arteries origins key to success. Coronary events after successful ASO are not uncommon. We describe rare case child who underwent an period with one (LAD) described as atretic left place. At age seven, he developed myocardial ischemia due retrograde flow steal phenomenon from LAD into pulmonary artery. The p...

Following recent advances in technology for hemodialysis, the number of patients with chronic renal failure receiving long-term hemodialysis remains to be increasing. Arteriosclerosis obliterans (ASO) has attracted attention as a significant clinical problem in hemodialysis patients. Although several epidemiological studies on the development of ASO in hemodialysis patients are reported, there ...

While studying transgenic mice that overexpress human wildtype alpha-synuclein (Thy1-ASO, ASO) for typical brain alpha-synucleinopathy and central nervous system neuropathology, we observed progressive functional changes in the gastrointestinal and other peripheral organs. A more systematic study revealed that the gastrointestinal tract in ASO mice showed severe distension and blockage of the l...