Objective: Bioactive glass 45S5 is a surface reactive glass-ceramic biomaterial, developed in 1969. BAG 45S5 with particle size of 20-60 nm has the ability of bone regeneration, broad spectrum antibacterial effect, repairs and replaces diseased or damaged bone. The aim of this study was to evaluate the antibacterial activity and determine MIC and MBC values of nano-BAG45S5 on Streptococcus mu...

Bioactive glasses (BAGs) are highly interesting materials for bone regeneration applications in orthopedic and dental defects. It is quite well known that ionic release from BAGs influences cell behavior and function. Mindful of the clinical scenario, we hypothesized that local cell populations might additionally physically interact with the implanted BAG particles and respond differently than ...

Osteoporosis is a disease characterized by structural deterioration of bone tissue, leading to skeletal fragility with increased fracture risk. Calcium phosphates (CaPs) are widely used in bone tissue engineering strategies as they have similarities to bone apatite except for the absence of trace elements (TEs) in the CaPs. Bioactive glasses (BGs) have also been used successfully in clinic for ...

The objective of the study was to compare the acid neutralizing ability and shear bond strength (SBS) of three different types of orthodontic adhesives containing bioactive glasses (BAGs). 45S5, 45S5F and S53P4 BAGs were prepared using the melting technique and ground to fine particles. Orthodontic adhesives containing three types of BAGs were prepared as follows: 52.5% 45S5 BAG + 17.5% glass (...

The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption the bone surrounding implant and improve osseointegration, respectively. However, presence pores as well poor adherence brittle behavior inherent glassy affect service implants from these samples. Therefore, they need be optimized. In this work,...

Reconstruction and augmentation of the alveolar bone defects pose a challenge for dental surgeons due to its complex structure. The primary objective tissue engineering is regenerate or replace damaged tissues organs including with grafts, cells, biological molecules. 45S5-bioglass (45S5-BG), superior osteoconductive osteoinductive abilities, has been at forefront engineering, regeneration, per...

PURPOSE To determine the abrasivity of a 45S5 bioactive glass based toothpaste on enamel as a function of the particle size and shape of the glass. METHODS 45S5 glass was synthesized ground and sieved to give various particle sized fractions < 38, 38-63 and 63-110 microns. Two different grinding routes were used: percussion milling and ball milling. The glass powders were formulated into toot...

CuO, Fe2O3, MnO2 and ZnO substituted 45S5 bioactive glasses were prepared. Glass derived Bioactive Glass ceramics were obtained through controlled crystallization of bioactive glasses. The formed crystalline phases in bioactive glass ceramics were identified using X ray diffraction (XRD) analysis. Density and ultrasonic wave velocities of bioactive glasses and glass ceramics were measured and u...

The effect of the ionic products of Bioglass 45S5 dissolution on the gene-expression profile of human osteoblasts was investigated by cDNA microarray analysis of 1,176 genes. Treatment with the ionic products of Bioglass 45S5 dissolution increased the levels of 60 transcripts twofold or more and reduced the levels of five transcripts to one-half or less than in control. Markedly up-regulated ge...

Molecular dynamics simulations of Na(+)/H(+)-exchanged 45S5 Bioglass® models reveal that a large fraction of the hydroxyl groups introduced into the proton-exchanged, hydrated glass structure do not initially form covalent bonds with Si and P network formers but remain free and stabilised by the modifier metal cations, whereas substantial Si-OH and P-OH bonding is observed only at higher Na(+)/...