نتایج جستجو برای: فاکتور cox2

تعداد نتایج: 14897  

2014
Zhi-Ming Wang Jie Liu Hong-Bo Liu Ming Ye Yu-Fei Zhang Dong-Sheng Yang

BACKGROUND The prognostic significance of COX2 for survival of patients with oral cancer remains controversial. Thus, the meta-analysis was performed in order to identify COX2 expression impact on prognosis of oral cancer. METHOD Relevant literatures were searched using the following electronic databases without any language restrictions: Web of Science, the Cochrane Library Database, PubMed,...

2011
Hee Sung Kim Hye Seung Lee Woo Ho Kim

PURPOSE This study was undertaken to evaluate the significance of cyclooxygenase-2 (COX2) overexpression and the expression of somatostatin receptor (SSTR) subtypes in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). MATERIALS AND METHODS Two hundred and forty-seven cases of GEP-NET, comprising 86 foregut and 156 hindgut primary NETs, and 5 metastatic NETs in the liver, were studied r...

2016
Dongxin Hu Mingyan Zhang Shuai Wang Zhou Wang

BACKGROUND The poor prognosis of esophageal squamous cell carcinoma (ESCC) is attributed to a high recurrence rate after surgery. Cyclooxygenase 2 (COX2) is an important regulator of cell growth, differentiation, apoptosis, and transformation. COX2 overexpression is significantly associated with the tumorigenesis and progression of diverse cancers; however, its expression and significance in ES...

2016
Chiang-Wen Lee Zih-Chan Lin Stephen Chu-Sung Hu Yao-Chang Chiang Lee-Fen Hsu Yu-Ching Lin I-Ta Lee Ming-Horng Tsai Jia-You Fang

We explored the regulation of filaggrin, cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) expression induced by urban particulate matter (PM) in human keratinocytes. In addition, we investigated the signaling pathways involved in PM-induced effects on COX2/PGE2 and filaggrin. PMs induced increases in COX2 expression and PGE2 production, and decreased filaggrin expression. These effects were ...

Journal: :The Plant cell 1993
J. Gu D. Miles K. J. Newton

The nonchromosomal stripe (NCS6) mutation of maize is a partial deletion of the mitochondrial cytochrome oxidase subunit 2 (Cox2) gene. The Cox2 deletion and a narrow yellow striping phenotype are inherited together in a maternal fashion. The striped plants are heteroplasmic for mutant and normal Cox2 genes. Only the mutant Cox2 gene is detected within the yellow stripes, whereas both normal an...

2015
Bernadette Y. Hsu Yong Ho Bae Keeley L. Mui Shu-Lin Liu Richard K. Assoian Sanjay Kumar

Apolipoprotein E3 (apoE3) is thought to protect against atherosclerosis by enhancing reverse cholesterol transport. However, apoE3 also has cholesterol-independent effects that contribute to its anti-atherogenic properties. These include altering extracellular matrix protein synthesis and inhibiting vascular smooth muscle cell proliferation. Both of these cholesterol-independent effects result ...

Journal: :Anticancer research 2013
Adam Elzagheid Fatma Emaetig Lamia Alkikhia Abdelbaset Buhmeida Kari Syrjänen Omran El-Faitori Matti Latto Yrjö Collan Seppo Pyrhönen

BACKGROUND Despite compelling evidence from the genetic background and clinical studies indicating that cyclooxygenase-2 (COX2) up-regulation is a key step in carcinogenesis of colorectal carcinoma (CRC), controversy regarding its role as a prognostic factor exists. However, all evidence indicates that increased COX2 activity promotes progression of CRC. This study, aimed to evaluate the expres...

Journal: :The journal of contemporary dental practice 2012
Maryam Amirchaghmaghi Nooshin Mohtasham Pegah Mosannen Mozaffari

AIM To compare cyclooxygenase 2 expression (COX2-E) between normal, oral leukoplakia lesions and different grades of oral squamous cell carcinoma (SCC). MATERIALS AND METHODS Around 90 paraffin embedded blocks consisting of 45 SCC, 15 leukoplakia and 17 controls were selected for immunohistochemistry (IHC) for detection of COX2- E. COX2-E was divided in four grades, as A (0-10%), B (11- 40%),...

2017
Hirosato Kanda Kimiko Kobayashi Hiroki Yamanaka Masamichi Okubo Koichi Noguchi

Prostaglandins (PGs) are typical lipid mediators that play a role in homeostasis and disease. They are synthesized from arachidonic acid by cyclooxygenase 1 (COX1) and COX2. Although COX2 has been reported to be upregulated in the spinal cord after nerve injury, its expression and functional roles in neuropathic pain remain unclear. In this study, we investigated the expression of Cox2, PGI2 sy...

Journal: :Cancer research 2000
M Toyota L Shen M Ohe-Toyota S R Hamilton F A Sinicrope J P Issa

Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of COX2 has been reported in a subset of colorectal and gastric cancers. Aberrant CpG island methylation and associated transcriptional silencing are c...

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