نتایج جستجو برای: لیزر dfg
تعداد نتایج: 4783 فیلتر نتایج به سال:
Tyrosine kinases transmit cellular signals through a complex mechanism, involving their phosphorylation and switching between inactive and active conformations. The cancer drug imatinib binds tightly to several homologous kinases, including Abl, but weakly to others, including Src. Imatinib specifically targets the inactive, so-called "DFG-out" conformation of Abl, which differs from the prefer...
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase
Protein tyrosine kinases differ widely in their propensity to undergo rearrangements of the N-terminal Asp-Phe-Gly (DFG) motif of the activation loop, with some, including FGFR1 kinase, appearing refractory to this so-called 'DFG flip'. Recent inhibitor-bound structures have unexpectedly revealed FGFR1 for the first time in a 'DFG-out' state. Here we use conformationally selective inhibitors as...
We report on recent developments of widely tunable, continuous-wave (CW) laser sources based on difference-frequency generation (DFG) in nonlinear optical materials. The state-of-the-art of CW DFG technology will be reviewed. Applications of the DFG-based laser source to high-resolution molecular spectroscopy and trace gas detection will be presented. New development trends of DFG will be discu...
Automated process discovery is a mining operation that takes as input an event log of business and generates diagrammatic representation the process. In this setting, common generated by commercial tools directly-follows graph (DFG). some real-life scenarios, DFG contains hundreds edges, hindering its understandability. To overcome shortcoming, generally offer possibility filtering edges in DFG...
The focus on glutamate neurotransmission presented in the October 2005 CNS Spectrums 1,2 was a turning point in the conceptualization of overconsolidational fear disorders, such as post-traumatic stress disorder (PTSD). We would like to draw attention to a potential confounding factor that can be controlled in future studies. Dietary free glutamate (DFG) is not only a common flavor enhancer (mo...
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