Chronic liver disease is often found in HIV infected patients. LPV as first choice drug is often used over long time periods. TDM as a tool in patients care is important but the knowledge of LPV-plasma-levels in patients with chronic liver disease remain uncertain. With this retrosepective analysis we want to show if there are differences in LPV-plasma-levels between patients with and without c...

LPVTools is a toolbox aimed at helping users design parameter dependent control systems using the Linear Parameter-Varying framework (LPV). LPVTools contains data structures to represent LPV systems in MATLAB® and Simulink®, and a collection of functions and tools for model reduction, analysis, synthesis and simulation in the LPV framework.

Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes. In this study, amino acid prodrugs of LPV were designed and investigated for their potential to circumvent efflux processes and first pass effects. Three amino acid...

The purpose of this study was to determine if switching to an Lopinavir/ritonavir (LPV/r)-containing regimen resulted in greater immune reconstitution in patients with immunologic failure despite complete viral suppression with highly active antiretroviral therapy (HAART). Twenty patients with partial or no immune response to HAART despite viral suppression were enrolled. Ten were randomized to...

Lopinavir/ritonavir (LPV/r) is the first ritonavir-boosted protease-inhibitor used in second-line anti-retroviral treatment (ART) in resource-limited regions. To evaluate the efficacy and safety outcomes of LPV/r in treatment-naïve and -experienced HIV-infected adults and pregnant women, we performed a meta-analysis of randomized controlled trials. Ten cohorts from 8 articles involving 2,584 AR...

This paper investigates an output tracking problem for the vapor compression cycle in automotive Air Conditioning (A/C) systems using Linear Parameter Varying (LPV) techniques. Stemming from a recently developed first-principle A/C model, Jacobian linearization is first exploited to develop an LPV-based model that is nonlinearly dependent on time-varying system parameters such as evaporator pre...

Hamster embryo cells were transformed by African green monkey lymphotropic papovavirus (LPV). The transformed cells contained intranuclear T-antigens demonstrable by fluorescent antibody staining with hamster anti-LPV serum. Analysis of uncloned and cloned lines of transformed cells for LPV sequences revealed that the viral DNA was present as free nonintegrated and integrated genomes; there wer...

Fuel efficiency, endurance, and noise requirements are pushing modern aircraft to lighter, more flexible designs. This causes the structural modes to occur at lower frequencies increasing the coupling with the rigid body dynamics. The traditional approach to handle aeroservoelastic interaction is to design gain-scheduled flight control laws based on the rigid body dynamics and then use filters ...

An approach to extend classical robustness margins to linear parameter varying (LPV) systems is presented. LPV systems are often used to model aircraft dynamics that are highly dependent on the operating conditions such as altitude and airspeed. Classical gain and phase margins are evaluated in the frequency domain and therefore cannot be applied to LPV systems. The proposed approach is based o...

Presently, linear parameter varying (LPV) systems are broadly used in a wide range of applications such as in aerospace, energy, health, mechatronics, process control, computational systems, etc. Essentially, an LPV system is a linear system whose parameters are functions of a scheduling signal. It can be described by state-space or input/output models, in continuous or discrete-time. The incre...