Objective(s): This study aimed to investigate the effect of Shogaol on dextran sodium sulfate (DSS)- induced ulcerative colitis (UC) in mice compared to an immune-suppressant chemotherapeutic medicine, known as 6-thioguanine (6-TG). Materials and Methods: Thirty-six adult BALB/c mice were divided into six groups: group 1 (positive control): no DSS exposure and no treatment; group 2 (negative co...

The pathogenic mechanisms responsible for inflammatory bowel disease, especially ulcerative colitis (UC), are poorly understood. As an animal model, the oral administration of dextran sulfate sodium (DSS) induces colitis, which exhibits several clinical and histological features similar to UC. However, the pathogenic factors responsible for DSS-induced colitis and above all, the intestinal micr...

Past studies suggested that decision support systems (DSS) must be an “enabling” system aiming to enhance users’ capabilities and to leverage their skills and intelligence. This suggests that users be the center of DSS and users’ characteristics be an important factor of explaining their DSS acceptance behavior. Since DSS are aimed to work in semi-structured and unstructured task environment, p...

While DSS development methodologies and implementation research are abound in the DSS literature, a gap still exists in terms of the ability to provide a holistic conceptual structure for improving the management and development of decision support systems, the ability to capture and share understanding of key DSS development processes, and most notably, the ability to provide guidance for DSS ...

Background: Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. Aims: To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS). Methods: DSS coliti...

The mechanisms responsible for human inflammatory bowel disease remain poorly understood. The pathogenic factors for dextran sulfate sodium (DSS)-induced colitis, one of the experimental animal colitis models, also remain unknown. Furthermore, detailed studies on DSS metabolism in the gut lumen have not been reported. Therefore, we investigated DSS metabolism in the mouse gut lumen and report t...

Terms such as ‘adaptive’ and ‘evolutionary’ capture the organic nature of the development of a decision support system (DSS). However, they are rarely defined in DSS research and their meaning varies widely in the research literature. The aim of this paper is to contribute to decision support systems theory by clarifying the nature of the evolutionary process of a DSS. Using insight from the th...

BACKGROUND Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS). METHODS DSS colit...

This paper illustrates an evaluation methodology for DSS software selection. The methodology incorporates three stages: 1) DSS software screening; 2) generator evaluation; and, 3) specific DSS design. Initially, developing a short list through screening of DSS software determines whether an appropriate package exists and narrows the field of available generator products for detailed considerati...