Regulation of nuclear import is fundamental to eukaryotic biology. The majority of nuclear import pathways are mediated by importin-cargo interactions. Yet not all nuclear proteins interact with importins, necessitating the identification of a general importin-independent nuclear import pathway. Here, we identify a code that determines importin-independent nuclear import of ankyrin repeats (ARs...

Complex regulatory networks control cell fate and the development of organs and tissues in multicellular organisms. But what mechanisms initiate the necessary global changes in patterns of gene expression? What regulates the regulators of organismal development? The nuclear actin-related proteins (ARPs) participate in macromolecular chromatin-remodeling machines that regulate the transcription ...

The precise lineage between neural stem cells and mature astrocytes remains poorly defined. To examine astrocyte development, we have characterized glial precursors from neural tissue derived from early embryonic ages. We show that CD44 identifies an astrocyte-restricted precursor cell (ARP) that is committed to generating astrocytes in vitro and in vivo in both rodent and human tissue. CD44+ c...

Perchlorate can be destroyed by Advanced Reduction Processes (ARPs) that combine chemical reductants (e.g., sulfite) with activating methods (e.g., UV light) in order to produce highly reactive reducing free radicals that are capable of rapid and effective perchlorate reduction. However, natural organic matter (NOM) exists widely in the environment and has the potential to influence perchlorate...

Coupled Fire-Atmosphere Modeling of Wildland Fire Spread Using DEVS-FIRE and ARPS 1 Nathan Dahl, Haidong Xue, Xiaolin Hu, and Ming Xue 2 Rosenstiel School of Marine and Atmospheric Science, University of Miami, 4600 Rickenbacker Causeway, Miami, FL 33149 3 Department of Computer Science, Georgia State University, P.O. Box 5060, Atlanta, GA 30302 4 Center for Analysis and Prediction of Storms, 1...

Complex regulatory networks control cell fate and the development of organs and tissues in multicellular organisms. But what mechanisms initiate the necessary global changes in patterns of gene expression? What regulates the regulators of organismal development? The nuclear actin-related proteins (ARPs) participate in macromolecular chromatin-remodeling machines that regulate the transcription ...

With Federated Identity Management (FIM) protocols, service providers can request user attributes, such as the billing address, from the user’s identity provider. Access to this information is managed using so-called Attribute Release Policies (ARPs). In this paper, we first analyze various shortcomings of existing ARP implementations; then, we demonstrate that the eXtensible Access Control Mar...