نتایج جستجو برای: مدل arno
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زمینه و هدف: شبیه سازی بارش- رواناب از محورهای اصلی هیدرولوژی علمی و مدیریت محیط زیست است. بنابراین محققان، پیوسته علاقه مند به یافتن روش های جدید برای این مسأله و اصلاح مدل ها یا روش های مدل سازی موجود هستند. روش بررسی: در این تحقیق، جریان روزانه رودخانه در خروجی یک حوضه آبریز در جنوب غربی ایران، با استفاده از یک مدل بارش- رواناب پیوسته مفهومی شبیه سازی شد. در مواجهه با مشکل کفایت آمار حوضه،...
Constraints programming allows the composer to synthesize a score by describing it. Arno is a program for computer assisted composition which extends Common Music (CM) by means of constraints programming using Screamer. In Arno parameters of CM elements in a CM container can be declared nondeterministically using finite domains — instead of single values. Constraints are expressed as predicates...
The small GTPase Arf6 regulates endocytosis, actin dynamics, and cell adhesion, and one of its major activators is the exchange factor Arf nucleotide-binding site opener (ARNO), also called cytohesin-2 [1, 2]. ARNO must be recruited from the cytosol to the plasma membrane in order to activate Arf6, and in addition to a Sec7 nucleotide-exchange domain it contains a C-terminal pleckstrin homology...
Recycling of internalized integrins is a crucial step in adhesion remodeling and cell movement. Recently, we determined that the ADP-ribosylation factor-guanine nucleotide exchange factors (ARF-GEFs) cytohesin 2/ARNO and cytohesin 3/GRP1 have opposing effects on adhesion and stimulated β1 integrin recycling even though they are very closely related proteins (80% sequence identity). We have now ...
The EGFR instructs complex cellular programs by generating robust signals of defined strength and duration. To preserve signal identity and guard cells against the oncogenic risk generated by unabated signaling, it is imperative that EGFR be tightly regulated. In this framework, the ligand-dependent transition of EGFR from an inactive state to a catalytically competent one is regarded as a key ...
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