In an attempt to elucidate whether there is a specific 1-adrenergic receptor ( 1-AR) subtype involved in the genesis or maintenance of hypertension, the 1D-AR subtype was evaluated in a model of salt-induced hypertension. The 1D-AR–deficient ( 1D / ) and control ( 1D / ) mice (n 8 to 14 in each group) were submitted to subtotal nephrectomy and given 1% saline as drinking water for 35 days. Bloo...

Qu, Yongxia, Ghayath Baroudi, Yuankun Yue, Nabil El-Sherif, and Mohamed Boutjdir. Localization and modulation of 1D (Cav1.3) L-type Ca channel by protein kinase A. Am J Physiol Heart Circ Physiol 288: H2123–H2130, 2005. First published December 22, 2004; doi:10.1152/ajpheart.01023.2004.— 1D L-type Ca channel was assumed to be of neuroendocrine origin only; however, 1D L-type Ca channel knockout...

To investigate the physiological role of the alpha(1D)-adrenergic receptor (alpha(1D)-AR) subtype, we created mice lacking the alpha(1D)-AR (alpha(1D)(-/-)) by gene targeting and characterized their cardiovascular function. In alpha(1D)-/- mice, the RT-PCR did not detect any transcript of the alpha(1D)-AR in any tissue examined, and there was no apparent upregulation of other alpha(1)-AR subtyp...

compound n2, n3, n7, n8, 1, 4, 5, 6, 9, 10-decaphenyltetradecahydrodipyrazino [2, 3-b: 2, 3-e] pyrazine-2, 3, 7, 8-tetraamine (4) was prepared by condensation of 1, 1′, 2, 2′-tetrakis (phenylamino) ethane (1d) and glyoxal in etoh or i-proh. also, reaction of 1d with glyoxal in equimolare in etoh resulted 5,6-bis (ethoxy)-n2, n3, 1, 4-tetraphenylhexahydro-2, 3-pyrazinediamine (5). the natures of...

Integrins play a pivotal role in proliferation, differentiation, and survival in skeletal and cardiac myocytes. The beta(1D)-isoform of the beta(1)-integrin is specifically expressed in striated skeletal muscle. However, little is known about the role and the mechanisms by which the splice variant beta(1D)-integrin regulates myogenesis and mechanotransduction. We observed that cyclic mechanical...

Due to the enhanced piezoelectric properties, excellent mechanical properties and tunable electric properties, one-dimensional (1D) piezoelectric materials have shown their promising applications in nanogenerators (NG), sensors, actuators, electronic devices etc. To present a clear view about 1D piezoelectric materials, this review mainly focuses on the characterization and optimization of the ...