Voltage-gated calcium channels represent a heterogenous family of calcium-selective channels that can be distinguished by their molecular, electrophysiological, and pharmacological characteristics. We report here the molecular cloning and functional expression of three members of the low voltage-activated calcium channel family from rat brain (alpha(1G), alpha(1H), and alpha(1I)). Northern blot...

A patient with progressive muscular atrophy was assessed for the disease-associated genes by next-generation sequencing technology and exon trap and sequence analysis. The results of the investigation identified 399 genes, covering all exons in addition to 10 bp on either side, which are specific to 659 types of neuromuscular disorders, including hypotypes. Exon capture and sequence analysis re...

Interstitial collagen gives fetal membranes tensile strength, and membrane rupture has been attributed to collagen degradation. A polymorphism at -1607 in the matrix metalloproteinase-1 (MMP-1) promoter (an insertion of a guanine (G)) creates a core Ets binding site and increases promoter activity. We investigated whether this polymorphism is functionally significant for MMP-1 expression in amn...

An experiment was conducted from September 2019 to March 2020 examine the effect of different combination foliar applicable fertilizers on Hybrid tea rose cultivar Mohana. The study performed with 9 treatments (T1-RDF, T2- KNO3 2.5g/l, T3- 5.0g/l, T4- Soluble fertilizer (Sujala) 1g/l, T5- 2 g/l, T6- 1g/L+ T7- 1 g/l + 1.5g/l, T8- 1g/L 2g/l, T9- 1g/l+ 2.5g/l) and 3 replications. From this T8 (KNO...

While it is well recognized that pulmonary deposition of inhaled particles is lowered in microgravity (μG) compared with gravity on the ground (1G), the absence of sedimentation causes fine particles to penetrate deeper in the lung in μG. Using quantitative magnetic resonance imaging (MRI), we determined the effect of gravity on peripheral deposition (DEPperipheral) of fine particles. Aerosoliz...

We consider the problem where is an unknown permutation on f0; 1; : : :; 2 n ?1g, y 0 2 f0; 1; : : :; 2 n ? 1g, and the goal is to determine the minimum r > 0 such that r (y 0) = y 0. Information about is available only via queries that yield x (y) from any x 2 f0; 1; : : :; 2 m ? 1g and y 2 f0; 1; : : :; 2 n ? 1g (where m is polynomial in n). The main resource under consideration is the number...

We study the problem of determining the largest d of a non-Denniston maximal arc of degree 2 generated by a fp; 1g-map in PGð2; 2Þ via a recent construction of Mathon [9]. On one hand, we show that there are fp; 1g-maps that generate non-Denniston maximal arcs of degree 2ðmþ1Þ=2, where md 5 is odd. Together with Mathon’s result [9] in the m even case, this shows that there are always fp; 1g-map...

the pile-raft foundation is a combination of a raft foundation with piles. pile-raft foundation has been widely designed, assuming all structure loads to be transferred to piles without considering contribution of the load taken by contact surface between raft and soil. methods of analysis currently used in practice are based upon relatively conservative assumptions of soil behavior or on the l...