Aberrant methylation has been shown to trigger the inactivation of tumor suppressor genes during tumorigenesis. MicroRNAs (miRNAs) have been found deregulated in human colorectal cancer (CRC), and some of them may function as tumor suppressor genes. Here, we investigated CpG island promoter hypermethylation as a potential mechanism underlying miRNA disruption and identifed methylation-sensitive...

immunoglobulin, the clinical skin severity scores were lower in FcRg-/NC/Tnd mice by half than in conventional WT mice. On the other hand, there were no differences in both scratching behavior elicited by dermatitis and Th1/Th2 cytokine production between 2 groups of mice. In the skin lesion of FcRg null mice, mild epidermal hyperplasia and immune cell infiltration were observed. Particularly, ...

Remember to complete the entire handout before precept. In this handout, we cover the following new materials: • Using summary() to obtain the summary statistics of a linear regression model. • Using coef() to obtain coefficients from a linear regression model. • Using predict() to generate predicted values for the outcome variable based on an estimated linear regression model. • Using lm() to ...