1. Abstract 2. Introduction 3. Signaling Pathways Involved in Megakaryocyte Maturation 3.1. Thrombopoietin 3.2. TPO-Initiated Signaling in Megakaryocytes 3.3. Phosphatidylinositol 3-kinase 3.4. Mitogen Activated Protein Kinases 3.5. Stromal Cell-Derived Factor 1 3.6. Immediate Early Gene X-1 3.7. The Src Family Kinase; Lyn 4. Transcription Factors Associated with Megakaryopoiesis 4.1. GATA-1 an...

The world population of approx. 7.1 billion will grow by 17–54% by 2050. The world economy in 2050 will be four times larger than today and is projected to need 80% more energy in 2050. And, global greenhouse gas (GHG) emissions are on track to increase by 50%, primarily due to growth in energy-related CO2 emissions. The current boom in petroleum resources extracted by enhanced hydrocarbon reco...

he ultimate goal of the RoboCup initiative is stated as follows [1]: By mid-21st century, a team of fully autonomous hu-manoid robot soccer players shall win the soccer game, comply with the official rule of the FIFA, against the winner of the most recent World Cup. We consider this goal from the perspective of how close we are to it and what has to be done to reach it. What does it mean to imp...

BACKGROUND Harvested wood products (HWPs) mitigate climate change through carbon storage, material substitution, and energy substitution. We construct a model to assess the overall climate change mitigation effect (comprising the carbon storage, material substitution, and energy substitution effects) resulting from HWPs in regions of Japan. The model allows for projections to 2050 based on futu...