Although modern medicine is well developed in most of the world, large sections of the population in developing countries especially in rural areas where more than 80% of the population live still rely on Traditional Medicine (TRM) for Primary Care (PHC) [1-5]. THPs include Traditional Healers (THs) and Traditional Birth Attendants (TBAs) [6]. Medicinal plants constitute 95% of the total compon...

Tissue resident memory (Trm) CD8 T cells represent a newly described memory T cell population. We have previously characterized a population of Trm cells that persists within the brain after acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm cells do not undergo recall expansion after dissociation from the tissue. Furthermore, ...

Respiratory virus infections, such as those mediated by influenza virus, parainfluenza virus, respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus (SARS-CoV), rhinovirus, and adenovirus, are responsible for substantial morbidity and mortality, especially in children and older adults. Furthermore, the potential emergence of highly pathogenic strains of influenza virus...

Certain cytokine gene polymorphisms have been shown to correlate with outcome of human leukocyte antigen (HLA) identical sibling donor stem cell transplantation (SCT), but in unrelated donor SCT such information is scarce. We have studied the association between cytokine gene polymorphism and transplant-related mortality (TRM) in 182 unrelated SCTs performed at a single center. We found associa...

T cells are the main orchestrators of protective immunity in the stomach; however, limited information on the presence and function of the gastric T subsets is available mainly due to the difficulty in recovering high numbers of viable cells from human gastric biopsies. To overcome this shortcoming we optimized a cell isolation method that yielded high numbers of viable lamina propria mononucle...

The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune ...

The ability of a single acoustic element to produce a compact time domain signal from a multi-mode solid cylindrical waveguide using a time-reversal mirror (TRM) is considered. Two single element longitudinal contact transducers were used to excite and receive multiple longitudinal modes in a fused quartz waveguide in a TRM experiment. The TRM is demonstrated to be effective with the limited in...

We demonstrate with synthetic seismic data the superresolution and super-stacking properties of time reversal mirrors (TRM). Tests on synthetic data show that TRM has the potential of exceeding the Rayleigh resolution limit by a factor of more than 9. This property is accompanied by the fact that TRM has a significant resilience to strong noise. Computer tests validate these properties by accur...

There is a prevailing conviction that if traditional medicine (TRM) or complementary and alternative medicine (CAM) are integrated into healthcare systems, modern scientific medicine (MSM) should retain its principal status. This paper contends that this position is misguided in medical contexts where TRM is established and remains vibrant. By reflecting on the Chinese policy on three entrenche...

The two-regime method (TRM) has been recently developed for optimizing stochastic reaction-diffusion simulations [11]. It is a multiscale (hybrid) algorithm which uses stochastic reaction-diffusion models with different levels of detail in different parts of the computational domain. The coupling condition on the interface between different modelling regimes of the TRM was previously derived fo...