نتایج جستجو برای: ژن cas2

تعداد نتایج: 15851  

Journal: :International journal of mycobacteriology 2015
Akbar Kanji Zahra Hasan Asho Ali Ruth McNerney Kim Mallard Francesc Coll Grant Hill-Cawthorne Mridul Nair Taane G Clark Ambreen Zaver Sana Jafri Rumina Hasan

BACKGROUND Mycobacterium tuberculosis (MTB) PE_PGRS genes belong to the PE multigene family. Although the function of PE_PGRS genes is unknown, it is hypothesized that the PE_PGRS genes may be associated with antigenic variability in MTB. MATERIAL AND METHODS Whole genome sequencing analysis was performed on (n=37) extensively drug-resistant (XDR) MTB strains from Pakistan, which included Lin...

Journal: :Cell 2015
Sy Redding Samuel H. Sternberg Myles Marshall Bryan Gibb Prashant Bhat Chantal K. Guegler Blake Wiedenheft Jennifer A. Doudna Eric C. Greene

CRISPR-Cas adaptive immune systems protect bacteria and archaea against foreign genetic elements. In Escherichia coli, Cascade (CRISPR-associated complex for antiviral defense) is an RNA-guided surveillance complex that binds foreign DNA and recruits Cas3, a trans-acting nuclease helicase for target degradation. Here, we use single-molecule imaging to visualize Cascade and Cas3 binding to forei...

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