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The PKC1 gene in the yeast Saccharomyces cerevisiae encodes protein kinase C that is known to control a mitogen-activated protein (MAP) kinase cascade consisting of Bck1, Mkk1 and Mkk2, and Mpk1. This cascade affects the cell wall integrity but the phenotype of Pkc1 mutants suggests additional targets which have not yet been identified. We show that a pkc1Delta mutant, as opposed to mutants in ...
22 Amphotericin B (AMB) is an effective antifungal agent. However, its therapeutic use is 23 hampered by its toxicity, mainly due to channel formation across kidney cell membranes 24 and disruption of post-endocytic trafficking. We previously described a safe, injectable 25 AMB-arabinogalactan (AG) conjugate with neutralized toxicity. Here we studied the 26 mechanism of toxicity of free AMB and...
Deoxynivalenol (DON), which is a toxic secondary metabolite generated by Fusarium species, is synthesized through two separate acetylation pathways. Both acetylation derivatives, 3-acetyl-DON (3ADON) and 15-acetyl-DON (15ADON), also contaminate grain and corn widely. These derivatives are deacetylated via a variety of processes after ingestion, so it has been suggested that they have the same t...
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