A new species of the genus Tylototriton is described from Ngoc Linh Mountain, Kon Tum Province, in Central Highlands Vietnam based on integrative taxonomy, namely by combining molecular and morphological evidence. ngoclinhensis sp. nov. differs all other congeners data, allopatric distribution, divergence. In terms genetic divergence, distinctly sister T. panhai (6.77%) ngarsuensis (12.36%) mit...

UNLABELLED Bipolar disorder (BD) is a psychiatric disease considered to polygenic with multiple factors in genetics, each of which is not dominant but collaborative during pathogenic progression. We describe a method that estimates the collaborative contribution to the disease between a certain well-studied pathway and the other candidate pathway using Gene Set Enrichment Analysis (GSEA). We de...

Chloroplasts and cyanobacteria contain genes encoding polypeptides homologous to some subunits of the mitochondrial respiratory NADH-ubiquinol oxidoreductase complex (NADH dehydrogenase). Nothing is known of the role of the NADH dehydrogenase complex in photosynthesis, respiration, or other functions in chloroplasts, and little is known about the specific roles of the perhaps 42 subunits of thi...

Complex I (CI) is the largest of the five multi-subunit complexes constituting the human oxidative phosphorylation (OXPHOS) system. Seven of its catalytic core subunits are encoded by mitochondrial DNA (ND (NADH dehydrogenase)1-6, ND4L (NADH dehydrogenase subunit 4L)), with mutations in all seven having been reported in association with isolated CI deficiency. We investigated two unrelated adul...

It has been suggested that mitochondrial dysfunction plays a role in metabolic disorders including obesity, diabetes, and hypertension. The fact that mitochondrial defects can be accumulated over time as a normal part of aging may explain why some individuals can eat all sorts of foods and remain at normal weight while they are young. However, around the fourth decade of life there is a trend t...

Abstract Background and Aims Mitochondrial DNA (mtDNA) abnormalities, as well complex inflammatory processes involved in the pathogenesis of DKD may be detected early course DKD. The aim study was to evaluate a potential relation mtDNA modifications blood urine with podocyte injury proximal tubule (PT) dysfunction type 2 diabetes mellitus (DM) patients. hypothesis according which changes relate...

This study deals with mitochondrial phylogenetic information of Japanese flounder in the Pacific coast of Tohoku Japan to estimate the genetic population subdivision that was undetectable by conventional population statistics. We determined complete sequences of mitochondrial NADH dehydrogenase subunit-2 (ND2) and subunit-5 (ND5) genes for 151 individuals from northern (Aomori and Iwate prefec...

A large-type sexannulate leech species, Orobdella ibukifukuyamai sp. nov. , from Kii-Oshima Island, Japan, is described based on morphologic and molecular data. Phylogenetic analyses using nuclear 18S rRNA, 28S histone H3, mitochondrial cytochrome c oxidase subunit I, tRNA Cys Met 12S Val 16S Leu NADH dehydrogenase 1 markers showed that O. formed a clade with the okanoi Nakano, 2016 yamaneae oc...

Mitochondrial dysfunction is a common mediator of disease and organ injury. Although recent studies show that inducing mitochondrial biogenesis (MB) stimulates cell repair and regeneration, only a limited number of chemicals are known to induce MB. To examine the impact of the β-adrenoceptor (β-AR) signaling pathway on MB, primary renal proximal tubule cells (RPTC) and adult feline cardiomyocyt...