Die experimentelle Softwareentwicklungsumgebung NORA strebt die Nutzbarmachung neuer Ergebnisse im Bereich Unifikationstheorie und Deduktionsverfahren für Softwarewerkzeuge an. Gruppiert um eine Bibliothek wiederverwendbarer Softwarekomponenten bietet NORA interaktive Werkzeuge zum Komponentenretrieval mit Spezifikationen und Verwendungsmustern, zum unifikationsbasierten Konfigurationsmanagemen...

Nora virus is a single stranded RNA picorna-like virus with four open reading frames (ORFs). The coding potentials of the ORFs are not fully characterized, but ORF3 and ORF4 are believed to encode the capsid proteins (VP3, VP4a, VP4b, and VP4c) comprising the virion. To determine the polypeptide composition of Nora virus virions, polypeptides from purified virus were compared to polypeptides de...

We hypothesized that multidrug resistance efflux pumps (MDRs) may be contributing to the drug resistance of enterococci. We recently identified potential MDR-encoding genes in the Enterococcus faecalis V583 genome. Among the putative MDRs, we found a gene that encodes a NorA homolog and have characterized this enterococcal MDR in the present study. A mutant from which the enterococcal NorA homo...

RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi. We detected viral small RNAs with a signature of Dicer-2 dependent small interfering RNAs in Nora virus infected Drosophila. Furthermore, we demonstrate that the Nora virus VP1 protein contains RNAi suppr...

Drosophila melanogaster is widely used to decipher the innate immune system in response to various pathogens. The innate immune response towards persistent virus infections is among the least studied in this model system. We recently discovered a picorna-like virus, the Nora virus which gives rise to persistent and essentially symptom-free infections in Drosophila melanogaster. Here, we have us...

The National Occupational Research Agenda (NORA) was first established in 1996 by the National Institute for Occupational Safety and Health (NIOSH) and its partners as a framework to guide occupational safety and health research for the decade that followed. The process to develop NORA resulted in 21 research priorities, which can be found in the original document. NORA arose from the recogniti...

Title: Traumatic Brain Injury Rehabilitation Outcomes in a Canadian Health Care Environment: A Comparison with the U.S. Model Systems Database Primary Presenter: Nora K. Cullen List of Authors: Nora K. Cullen, Matthew McInnes, Kristine Kelly, Kattleya Tirona Affiliation: Toronto Rehabilitation Institute

This paper presents a novel approach for the synthesis of dynamic CMOS circuits using Domino and Nora styles. As these logic styles can implement only non-inverting logic, conventional logic design approaches cannot be used for Domino/Nora logic synthesis. To overcome this problem, we have used a new concept called unate decomposition of Boolean functions. The unate decomposition expresses a ge...

This study elucidated the role of boeravinone B, a NorA multidrug efflux pump inhibitor, in biofilm inhibition. The effects of boeravinone B plus ciprofloxacin, a NorA substrate, were evaluated in NorA-overexpressing, wild-type, and knocked-out Staphylococcus aureus (SA-1199B, SA-1199, and SA-K1758, respectively). The mechanism of action was confirmed using the ethidium bromide accumulation and...