نتایج جستجو برای: ژن tmc1
تعداد نتایج: 15878 فیلتر نتایج به سال:
Background and Objective: TMC1 gene mutations are known as the most common causes of autosomal recessive non-syndromic hearing loss (ARNSHL) in different populations. According to large size of the TMC1 gene and the large number of identified mutations in this gene, application of polymorphic markers is suggested for carrier detection and prenatal diagnosis in families. In this study, informati...
BACKGROUND Tonotopy is one of the most fundamental principles of auditory function. While gradients in various morphological and physiological characteristics of the cochlea have been reported, little information is available on gradient patterns of gene expression. In addition, the audiograms in autosomal dominant non syndromic hearing loss can be distinctive, however, the mechanism that accou...
The molecular identity of the channel that mediates mechanotransduction by hair cells remains uncertain, despite being biophysically characterized since the late 1970s (Corey and Hudspeth, 1979). Two recent reports from Jeffrey Holt, Gwenaelle Géléoc, Andrew Griffith, and their colleagues suggested that the hair cell’s transduction channel is made up of members of the transmembrane channel (TMC...
The molecular identity of the channel that mediates mechanotransduction by hair cells remains uncertain, despite being biophysically characterized since the late 1970s (Corey and Hudspeth, 1979). Two recent reports from Jeffrey Holt, Gwenaelle Géléoc, Andrew Griffith, and their colleagues suggested that the hair cell’s transduction channel is made up of members of the transmembrane channel (TMC...
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