Lymphocyte GRK mRNA expression was measured by quantitative RT-PCR in 15 congestive heart failure patients: 5 in NYHA class-II treated with ACEI (IIA), 5 in NYHA class-II without ACEI (IIC) and 5 in NYHA class-III treated with ACEI (IIIA). GRK2 and GRK5 mRNA of IIIA were significantly higher than those in IIA. GRK mRNA expression level in IIA were significantly lower than those of IIC. These re...

Numerous trials have explored the role of CRT in heart failure (HF) patients across a range symptom severity. However, data on benefits with severe HF symptoms, i.e. NYHA class IV, are limited as such were not well represented prior clinical trials. Accordingly, more evidence is needed outcomes IV symptoms. To examine relative benefit ambulatory vs III functional status at time implantation. In...

conclusions male gender, history of hypertension, high nyha score, and the presence of cad predict lvef deterioration in patients with lbbb. objectives the present study aimed to identify underlying factors that predict left ventricular ejection fraction (lvef) deterioration in patients suffered from complete lbbb. patients and methods in a retrospective case-control study, the data of 220 cons...

Myosin light chains-1 (MLC-1) have been recently associated with the markers of heart function (NYHA, LVEF, NT-proBNP). Verification of the relationship between markers of heart function (New York Heart Association classification (NYHA), left ventricle ejection fraction determination (LVEF), N terminal prohormone of natriuretic peptide B type BNP (NT-proBNP) and concentrations of myosin light c...

This study reports the clinical follow-up (13 +/- 1 months) of 100 consecutive patients who underwent percutaneous mitral balloon valvotomy (PMV). Echocardiographic (n = 32) and cardiac catheterization (n = 37) data from this group are also included. Patients were divided into two groups by an echocardiographic score. PMV resulted in a good hemodynamic result (post-PMV mitral valve area, greate...

The purpose of the present study was to compare differences in physiological outcomes and health-related quality of life (HRQOL) in relation to degree of illness in patients with chronic heart failure (CHF) and to compare HRQOL in CHF patients with that of a normal Japanese population. One hundred and twenty-five patients with stable CHF (93 men, 32 women, mean age 63.3 ± 12.4 years) with left ...

INTRODUCTION Functional class is an important predictor of prognosis in chronic heart failure (CHF). However, it is often subjective and poorly reproducible. OBJECTIVE We sought to identify diagnostic markers of high functional class. METHODS We prospectively studied 37 patients with symptomatic CHF and ejection fraction<40%. The study protocol included clinical evaluation, echocardiography...