A new series of 4-aryl-1, 4-dihyropyridines possessing potent calcium channel blocking activity along with good vasodilatory profile by the modified Hantzsch condensation using trifluoroacetic acid as catalyst has been synthesized and reported from our laboratory. The present work describes chemo enzymatic approach for the enantioselective hydrolysis of a 1, 4dihydropyridine skeleton. In this s...

Purpose: Individuals complaining of tinnitus often attribute hearing problems to the tinnitus. In such cases some (or all) of their reported “tinnitus distress” may in fact be caused by trouble communicating due to hearing problems. We developed the Tinnitus and Hearing Survey (THS) as a tool to rapidly differentiate hearing problems from tinnitus problems. Method: For 2 of our research studies...

The passing of human tumour tissue through a series of immunodeficient nude mice (“serial passaging”) has been an important model system in cancer research for more than 40 years (Rygaard & Povlsen, 1969). Such xenograft models have the advantage of unlimited availability of live tumour tissue, allowing for repeated experiments on the same tumour. It has been shown by various techniques, includ...

• Bruit or thrill suggestive of a traumatic arteriovenous fistula • Expanding or pulsatile hematoma • Pulsatile or severe hemorrhage • Pulse deficit—pulses may be normal in patients with nonocclusive injuries that require surgical repair, such as intimal flaps or pseudoaneurysms • Thorough vascular and esophageal evaluation is required, even with minor neck wounds, if any abnormalities are evid...

Epistatic interactions, manifested in the effects of mutations on the phenotypes caused by other mutations, may help uncover the functional organization of complex biological networks1–3. Here, we studied system-level epistatic interactions by computing growth phenotypes of all single and double knockouts of 890 metabolic genes in Saccharomyces cerevisiae, using the framework of flux balance an...

Our laboratory recently reported the identification of a peptide region, QVNI, within the prion domain of the yeast protein Ure2 that may act as an initiation point for fibril formation.(1) This potential amyloid-forming region, which corresponds to residues 18-21 of Ure2, was initially identified by systematic cysteine scanning of the Ure2 prion domain. The point mutant R17C, and the correspon...