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BACKGROUND Ulinastatin (UTI) is a urinary trypsin inhibitor extracted and purified from urine of males. This study aimed to explore the effects of UTI on paraquat-induced-oxidative stress in human type II alveolar epithelial cells. METHODS The human type II alveolar epithelial cells, A549 cells, were cultured in vitro. The A549 cells were treated with different concentrations of paraquat (200...
BACKGROUND Population-based human immunodeficiency virus type 1 (HIV-1) RNA levels (viral load [VL]) are proposed metrics for antiretroviral therapy (ART) program effectiveness. We estimated population-based HIV RNA levels using a fingerprick-based approach in a rural Ugandan community implementing rapid ART scale-up. METHODS A fingerprick-based HIV RNA measurement technique was validated aga...
OBJECTIVES Hepatitis C virus in renal transplant recipients is an independent risk factor for sickness and death. It has been shown that one might limit hepatitis C virus progression in liver transplant recipients with sirolimus-based immunosuppression. The mammalian target of rapamycin is an influential molecule for the anti-hepatitis C virus action of interferon. We report our experience with...
Objective—Tumor necrosis factor(TNF) has been linked to obesity-related insulin resistance and impaired endothelium-dependent vasodilatation, but the mechanisms have not been elucidated. To investigate whether TNFdirectly impairs insulin-mediated vasoreactivity in skeletal muscle resistance arteries and the role of c-Jun N-terminal kinase (JNK) in this interference. Methods and Results—Insulin-...
Hammer and colleagues report on BKV-specific T-cell responses in peripheral blood mononuclear cells (PBMC) of 15 viremic kidney transplant recipients (1). After stimulation with overlapping peptides spanning the viral capsid protein VP1, interferon-c (IFNc )-producing CD4+ T cells were observed in 7 patients (47%), including 2 patients (13%) with a CD8+ T-cell response. All patients with a dete...
We recorded the manifestations of severe vitamin D deficiency (VDD) in 40 adolescents before and 3 and 6 months after treatment with a mega dose of cholecalciferol (10 000 IU kg(-1), max 600 000 IU). Significant improvement of symptoms related to VDD was reported in 34/40. Three months after the injection, serus calcium, phosphate, alkaline phosphatase and parathormone were normal in all adoles...
Urechis caupo is a burrow-dwelling filter feeder that captures suspended particles in a mucus net and irrigates its burrow with peristaltic body wall contractions. An electromagnetic flow meter was used to measure the burrow irrigation rates of 7 U. caupo in their natural burrows under normal tidal cycles. The average burrow irrigation rate of 266 ± 158 ml min–1 (mean ± SD) was much greater tha...
We report a rare case of acute human immunodeficiency virus (HIV) syndrome in a patient with chronic HIV infection with acute illness indistinguishable from acute retroviral syndrome. The patient presented with an acute febrile mononucleosis-like illness after increasing nonadherence to antiretroviral therapy. A marked increase in HIV RNA level of 1 220 000 copies/mL from less than 20 copies/mL...
IJABELEI) URIC ACTI) (as a 0.50 c./ml. solution in dilute fornmalin) and glucose (as a 5.0 .tc./ml. solution in saturated henzoic acid) were used. Tlmese were diluted with distilled water, and 0.20-mi. aliquots were placed in the bottom of 25-mm. test tui)es om25-nil. Erlenmeyer flasks and evaporated to dryimess. Dilutions were calculated to keep counting rates between 4000 and 2 ,000 cprn. As ...
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