Transcript dynamics of the Arabidopsis genome is captured in a high-confidence, realistic GGM(Graphical Gaussian Model)-based gene network that identifies co-regulation correlation of 22 000 genes across >150 conditions in specific clusters.

OBJECTIVE Response to intravenous immunoglobulin (IVIG) has been shown to predict response to splenectomy in adults with immune thrombocytopenic purpura (ITP). However, reports in children have been inconsistent. We sought to determine whether response to IVIG is predictive of response to splenectomy in children. METHODS Thirty-two assessable children were identified by a retrospective chart ...

A calcium protease which degrades neurofilaments was first observed in the fan worm Myxicola infundibulum and in the squid Loligo forbesi [l] and subsequently in a mammalian system [2,3]. Many of the polypeptides in Myxicola axoplasm are degradation products of the 160 000 and 150 000 M, polypeptides as has been shown by careful peptide mapping. Moreover, there is a high probability that they r...

A short abstract not more than c. 150 words should be submitted on a separate page. An article abstract should indicate the scope and the main points of the article. A report abstract should indicate the scope of the report, the methods used, and main results. Synopses should not have an abstract. Numerals and Units of Measure Use thousand million instead of billion or use 109. Run together num...

Fludarabine can exacerbate idiopathic thrombocytopenia (ITP) in chronic lymphocytic leukemia (CLL). We report 3 CLL patients with refractory fludarabine-associated ITP who responded to rituximab. The patients had Rai stages III, III, and IV disease. Before fludarabine treatment, the platelet counts were 141 000/microL, 118 000/microL, and 70 000/microL. ITP developed within week 1 of cycle 3 in...

OBJECTIVE To analyse trends in mortality from coronary heart disease (CHD) and cerebrovascular disease (CVD) over the period 1965 to 1998 in the European Union, other European countries, the USA, and Japan. METHODS AND RESULTS Data were derived from the World Health Organization database. In the European Union, CHD mortality in men rose from 146/100 000 in 1965-9 to 163/100 000 in 1975-9 and ...

Objective: To analyse trends in mortality from coronary heart disease (CHD) and cerebrovascular disease (CVD) over the period 1965 to 1998 in the European Union, other European countries, the USA, and Japan. Methods and results: Data were derived from the World Health Organization database. In the European Union, CHD mortality in men rose from 146/100 000 in 1965–9 to 163/100 000 in 1975–9 and ...

The gel-overlay technique with 125I-labelled calmodulin allowed the detection of several calmodulin-binding proteins of Mr 280 000, 150 000, 97 000, 56 000, 35 000 and 24 000 in canine cardiac sarcoplasmic reticulum. Only two calmodulin-binding proteins could be identified unambiguously. Among them, the 97 000-Mr protein that undergoes phosphorylation in the presence of Ca2+ and calmodulin, is ...