Radiation therapy is one of the most commonly used treatment modalities for cancer. Its purpose is to deliver prescribed radiation doses to cancerous targets using high energy radiation beams while sparing nearby healthy organs. The treatment planning process of radiotherapy is an optimization problem, where beam parameters, such as directions, shapes, and intensities, can be adjusted in simula...

Introduction There is an increased prevalence of Crohn’s disease (CD) in familial Mediterranean fever (FMF). Previous studies found that neither MEFV, nor NOD2/CARD15 may serve as susceptible genes, leading to FMF-CD comorbidity. In addition to NOD2/CARD15 polymorphism, ATG16L1 and IL-23R gene SNPs were also found to predispose to Crohn’s disease (CD). The role of these genes in the occurrence ...

OBJECTIVE To evaluate the safety and efficacy of ketoprofen in Transfersome® gel (IDEA-033) in comparison with a ketoprofen-free vehicle (TDT 064) for the treatment of osteoarthritis (OA) of the knee. METHODS Patients with knee OA (N = 866) were randomly assigned to receive topical IDEA-033 containing 100, 50, or 25 mg ketoprofen, or TDT 064 twice daily for 12 weeks, in a double-blind trial. ...

Joseph Amal Nathan Reactor Physics Design Division, Bhabha Atomic Research Centre, Mumbai-400085, India email:[email protected] Abstract: In this paper two conjectures are proposed based on which we can prove the first case of Fermat’s Last Theorem(FLT) for all primes p ≡ −1(mod 6). With Pollaczek’s result [1] and the conjectures the first case of FLT can be proved for all primes gr...

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Introduction Familial Mediterranean Fever (FMF) is an ethnic disease for Armenian population and represents a significant health care problem. Frequency of carriers of MEFV mutations is 1:3, and the prevalence of FMF is rather high (14-100:10000). During the period between 2003 and 2012 there was a 4.5-fold increase of the total number of children with FMF. Many of these cases have severe clini...