Debio 025 is a potent inhibitor of hepatitis C virus (HCV) replication (J. Paeshuyse et al., Hepatology 43:761-770, 2006). In phase I clinical studies, monotherapy (a Debio 025 dose of 1,200 mg twice a day) resulted in a mean maximal decrease in the viral load of 3.6 log(10) units (R. Flisiak et al., Hepatology 47:817-826, 2008), whereas a reduction of 4.6 log(10) units was obtained in phase II...

MARK DAVID BAKER*, VIVEK VASUDEV PAI**, NANDA AJAYAN*** & CHANDRAKANT DHAMALE**** *Nurse Volunteer, Promise Nepal/Bombay Leprosy Project, Mumbai, Maharashtra, India **Director, Bombay Leprosy Project, 11, Vidnyan Bhavan, VN Purav Marg, Sion, Chunabhatti, Mumbai – 400 022, India ***Non Medical Supervisor, Bombay Leprosy Project, 11, Vidnyan Bhavan, VN Purav Marg, Sion Chunabhatti, Mumbai – 400 0...

OBJECTIVES To determine whether tango dancing is as effective as mindfulness meditation in reducing symptoms of psychological stress, anxiety and depression, and in promoting well-being. DESIGN This study employed analysis of covariance (ANCOVA) and multiple regression analysis. PARTICIPANTS Ninety-seven people with self-declared depression were randomised into tango dance or mindfulness me...

The aims of this study were to determine and compare frictional resistance obtained by low-friction and conventional elastomeric ligatures in the presence of artificial saliva, and observe whether this variable changed after 21 days. Super Slick® low-friction elastomeric ligatures and conventional ligatures of the brands TP conventional® and Unitek® were placed on standard edgewise maxillary ce...

OBJECTIVE Vascular endothelial inflammation and enhanced oxidative stress are important factors in the pathogenesis of obstructive sleep apnea syndrome (OSAS). The aim of this study was to determine the levels of heat shock protein (HSP) 27, HSP70, HSP90, L-arginine, and asymmetric dimethylarginine (ADMA) in patients with OSAS and determine their relationship with cardiovascular (CV) risk facto...

OBJECTIVES/HYPOTHESIS This study was intended to evaluate prognostic factors and the role of postoperative radiotherapy (RT) in patients with adenoid cystic carcinoma (ACC) of the head and neck (ACCHN). STUDY DESIGN Retrospective study. METHODS Eighty-eight patients with ACCHN who underwent curative intent surgery with or without RT between 1991 and 2009 at a single institute were retrospec...

OBJECTIVE To measure the effect of routine perioperative lumbar drain placement during anterior skull base surgery on the frequency of: 1) tension pneumocephalus and 2) total intracranial complications. DESIGN Retrospective review of a series of patients (n = 161) who underwent the transglabellar/subcranial approach to lesions of the anterior skull base between December 1995 and November 2009...