Phonographic Encounters: Mapping Transnational Cultures of Sound, 1890–1945. Edited by Elodie A. Roy and Eva Moreda Rodríguez. London: Routledge, 2021. xv+268 pp. ISBN : 978-1-032-05711-8 - Volume 41 Issue 4

Despite advances in screening and treatment, colorectal cancer remains the second leading cause of cancer-related death in the United States. Cyclin-dependent kinases (Cdk) are deregulated in colorectal cancer by silencing of the Cdk inhibitor p16 and other mechanisms. We tested whether the small molecule Cdk inhibitor SNS-032 (formerly BMS-387032), which targets Cdk2, Cdk7, and Cdk9, can preve...

Introduction – Lunar meteorite Northwest Africa (NWA) 032 is an unbrecciated mare basalt, discovered in 1999, whose modal mineralogy is characterized by phenocrystic olivine, pyroxene and chromite, with a groundmass containing feldspar, pyroxene, ilmenite, troilite and other trace metals [1]. Shock melt occurs in veins throughout the sample as well. Fagan et al. [1] observed that the major elem...

Methods Hospital records and biochemical data were obtained for patients presenting to the paediatric infectious disease clinic with periodic fever syndromes between 2001 and 2011. 68 patients were identified but 30 were excluded as they had a clear focus of infection or no history of recurrent fever on review of the medical records. The clinical diagnosis, patient demographics, aetiology, feve...

Escudero, David. Neorealist Architecture: Aesthetics of Dwelling in Postwar Italy. Nombre del editor, traductor o coordinador. Abington, Oxon: Routledge, 2023, 978-1-032-23504-2, 222.

Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four o...

The sodium requirements, balance, excretion, patterns and composition of some pig tissues were studied in two feeding trials and a balance trial followed by an additional feeding period with terminal tissue composition analysis. The growth of pigs fed a corn-soybean meal diet without added salt was severely restricted. Results confirm that a sodium requirement of .09% of the diet is adequate an...