In cultures of Xenopus myotomal muscle cells and spinal cord (SC) some of the nerve-muscle contacts exhibit a high density of acetylcholine receptors (AChRs [Anderson et al ., 1977, /. Physiol. (Loud.) . 268:731-756, 757-773]) and synaptic ultrastructure (Weldon and Cohen, 1979, /. Neurocytol . 8:239-259) . We have examined whether similarly specialized contacts are established when the muscle ...

A cell culture line of human small cell (oat cell) carcinoma of the lung (NCI-H69) was studied for growth factor requirements for replication in serum-free medium. By a series of addition experiments, the combination of selenium (3x10~8 M), hydrocortisone (1CT8 M), insulin (5 fig/ml), transferrin (100 fig/ml), and 17ß-estradiol (10~8 M) (SHITE) added to Roswell Park Memorial Institute Medium 1...

•We identify 100 priority global water-research questions for the coming decade•The are in six thematic areas connecting local to scale•Questions about governance and knowledge production cut across all scales•These offer a shared framework interdisciplinary water research Water is vital resource critical sustainable development. Human survival, energy food production, healthy ecosystems depend...

I first summarize Baltag and Smets’ contribution to this volume, and praise their work. Then I compare the anti-lexicographic plausibility update that they propose to a proposal by Aucher, as an illustration of the difference between a qualitative and a quantitive formulation of updates. I quote Spohn’s original work that is at the root of research in plausibility updates and of the notion of a...

Previous studies from our laboratory showed that p21 can be phosphorylated by Pim-1 kinase in vitro , implying that part of the function of Pim-1 might involve influencing the cell cycle. In the present study, site-directed mutagenesis and phosphorylated-specific antibodies were used as tools to identify the sites phosphorylated by Pim-1 and the consequences of this phosphorylation. What we fou...