In pregnancy, α-adrenoceptor-mediated vasoconstriction is augmented in uterine radial arteries and is accompanied by underlying changes in smooth muscle (SM) Ca(2+) activity. This study aims to determine the Ca(2+) entry channels associated with altered vasoconstriction in pregnancy, with the hypothesis that augmented vasoconstriction involves transient receptor potential canonical type-3 (TRPC...

* Corresponding author. E-mail addresses: [email protected] (P. Li), [email protected] (W. Zheng). 1 The research was supported in part by the NSF grants DMS-0914595, DMS-1042958, and DMS-1151308. 2 The research was supported in part by China NSF grants 11031006 and 11171334, by the Funds for Creative Research Groups of China (Grant No. 11021101), by the National Magnetic Confinement Fus...

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA Molecular Oncology Group, McGill University, Montreal, Canada H3A 1A1...

Abstract Introduction Insomnia is one of the most prevalent health concerns in general population. Cognitive behavioural therapy (CBT) and pharmacological interventions are recommended for treatment insomnia. However, CBT can be expensive difficult to access, while use pharmacotherapy limited by reports adverse events. Due these limitations, there a strong need alternative measures manage Preli...