نتایج جستجو برای: 0464
تعداد نتایج: 41 فیلتر نتایج به سال:
Cells of B-cell chronic lymphocytic leukemia (B-CLL) are characterized by short telomeres despite a low proliferative index. Because telomere length has been reported to be a valuable prognosis criteria, there is a great interest in a deep understanding of the origin and consequences of telomere dysfunction in this pathology. Cases of chromosome fusion involving extremely short telomeres have b...
Primary cilia are sensory organelles that extend from the cell surface and senseextracellular signals. Endothelial primary cilia protruding from the inner surface of blood vessel wallssense changes in blood flow and convert this mechanosensation into an intracellular biochemical/molecular signal, which triggers a cellular response. Primary endothelial cilia dysfunction maycontri...
Despite the growth of terrorism literature in the aftermath of the 9/11 attacks, there remain several methodological challenges to studying certain aspects of terrorism. This is perhaps most evident in attempts to uncover the attitudes, motivations, and intentions of individuals engaged in violent extremism and how they are sometimes expressed in problematic behavior. Such challenges invariably...
PURPOSE To study the clinical profile and presentation of children with unilateral cataract. METHODS In this hospital-based, observational, cross-sectional study, patients 15 years of age or younger who presented with unilateral cataract were recruited. Cases of cataract secondary to causes such as trauma or uveitis were excluded. Age at detection and presentation, distance from the treatment...
The absence of biological markers allowing for the assessment of the evolution and prognosis of glioblastoma (GBM) is a major impediment to the clinical management of GBM patients. The observed variability in patients' treatment responses and in outcomes implies biological heterogeneity and the existence of unidentified patient categories. Here, we define for the first time three GBM patient ca...
Epidermal growth factor receptor (EGFR) is a clinical therapeutic target to treat a subset of non–small cell lung cancer (NSCLC) harboring EGFRmutants. However, some patientswith a similar kind of EGFRmutation show intrinsic resistance to tyrosine kinase inhibitors (TKI). It indicates that other keymolecules are involved in the survival of these cancer cells. We showed here that 2-[(aminocarbon...
Purpose: Vaccinia virus has strong potential as a novel therapeutic agent for treatment of pancreatic cancer. We investigated whether arming vaccinia virus with interleukin-10 (IL10) could enhance the antitumor efficacy with the view that IL10 might dampen the host immunity to the virus, increasing viral persistence, thus maximizing the oncolytic effect and antitumor immunity associated with va...
Many real-world systems are naturally modeled as hybrid stochastic processes, i.e., stochastic processes that contain both discrete and continuous variables. Examples include speech recognition, target tracking, and monitoring of physical systems. The task is usually to perform probabilistic inference, i.e., infer the hidden state of the system given some noisy observations. For example, we can...
Some dihydropyridines (DHPs), such as amlodipine and cilnidipine, have been shown to block not only L-type but also N-type Ca channels; therefore, DHPs are no longer considered as L-type-specific Ca channel blockers. However, selectivity of DHPs for Ca channel subtypes including N-, P/Q-, and R-types are poorly understood. To address this issue at the molecular level, blocking effects of 10 DHP...
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