INTRODUCTION Congenital myopathies (CM) often affect contractile proteins of the sarcomere, which could render patients susceptible to exercise-induced muscle damage. We investigated if exercise is safe and beneficial in patients with CM. METHODS Patients exercised on a stationary bike for 30 minutes, three times weekly, for 10 weeks at 70% of their maximal oxygen uptake (VO2max). Creatine ki...

PG 2131+066 is a composite–spectrum binary with a hot pulsating PG 1159-type pre–white dwarf and an early M-type main sequence star. Analysis of Whole Earth Telescope observations of the pulsating pre-white dwarf component provided an asteroseismological determination of its mass, luminosity, and effective temperature. These determinations allowed Kawaler et al. (1995) to determine the distance...

This paper provides a comprehensive examination of differences between relationship bank behavior for a set of borrowers that either underwent distress or filed for bankruptcy relative to normal times. Prior to distress, banks offer preferential contract terms in the form of lower interest rates and less collateral requirement to their relationship borrowers. After the onset of distress, banks ...

The activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) is dysregulated in a number of hematological and solid malignancies. Development of pharmacological STAT3 Src homology 2 (SH2) domain interaction inhibitors holds great promise for cancer therapy, and a novel class of salicylic acid-based STAT3 dimerization inhibitors that includes orally bioavai...

Abstract Study question Dose Testis expressed 44 (TEX44) gene associated with spermatogenesis and TEX44 mutations required for male infertility ? Summary answer is in testis participated spermatogenesis. And of may be involved risk asthenozoospermia lead to subfertile. What known already The World Health Organization estimates that 7-9 % population worldwide struggle infertility. Asthenoteratoz...

We derive limits on millicharged dark states, as well particles with electric or magnetic dipole moments, from the number of observed forward electron scattering events at Big European Bubble Chamber in 1982 CERN-WA-066 beam dump experiment. The states are produced by 400 GeV proton primarily through decays mesons dump, and lack excess places bounds extending up to masses. These improve all oth...

The necessity of catastrophe modeling is stipulated both by the essential increase of losses due to recent natural and man-caused hazards and by the lack of reliable real observation data. Earthquakes are considered as an example of unpredictable catastrophic events of a great destructive force. A brief overview of different approaches to mathematical modeling of lithosphere dynamics is present...