Reseña:Pedro Oliver Olmo (coord.), La tortura en la España contemporánea, Madrid, Los Libros de Catarata, 2020, ISBN 978-84-1352-077-3, 288 pp.

The bioactive lipid sphingosine-1-phosphate (S1P) and its receptors (S1P1-5) play critical roles in many pathologic processes, including cancer. The S1P axis has become a bona fide therapeutic target in cancer. JTE-013 [N-​(2,​6-​dichloro-​4-​pyridinyl)-​2-​[1,​3-​dimethyl-​4-​(1-​methylethyl)-​1H-​pyrazolo[3,​4-​b]pyridin-​6-​yl]-​hydrazinecarboxamide], a known S1P2 antagonist, suffers from in...

Previously we demonstrated that sphingosine 1-phosphate receptor 1 (S1PR(1)) played a prominent, but not exclusive, role in enhancing the excitability of small-diameter sensory neurons, suggesting that other S1PRs can modulate neuronal excitability. To examine the potential role of S1PR(2) in regulating neuronal excitability we used the established selective antagonist of S1PR(2), JTE-013. Here...

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Drugs that exhibit insurmountable antagonism are proposed to provide improved clinical efficacy through extended receptor blockade. Long-term suppression of the gonadotropin-releasing hormone receptor (GnRHR) is an important therapeutic approach for a number of sex hormone-dependent diseases. In this study, we describe the mechanism and structural components required for insurmountable activity...

aUniversité de Pau et des Pays de l’Adour LMAP UMR 5142 and Inria CAGIRE Team – Avenue de l’Université – 64 013 Pau, France bInria CAGIRE Team, Université de Pau et des Pays de l’Adour LMAP UMR 5142 – Avenue de l’Université – 64 013 Pau, France cCNRS, Université de Pau et des Pays de l’Adour LMAP UMR 5142 and Inria CAGIRE Team – Avenue de l’Université – 64 013 Pau, France dGhent University – De...