Methods for the quantitative determination of steroids have been developed, based on their specific chemical or physicochemical properties. The Zimmermann reaction (1) and the Kober reaction (2) have been found useful in the quantitative determination of certain individual steroids occurring in urine. Modifications of these reactions have been reported by Callow et al. (3), Holtorff and Koch (4...

Fractional dextran clearances have been extensively used to study glomerular size selectivity. We report on an analysis of different laboratory procedures involved in measuring fractional dextran clearances. The deproteinization of plasma samples by 20% trichloroacetic acid (TCA) revealed a protein contamination of 0.2% +/- 0.3%, whereas both 5% TCA and zinc sulfate deproteinization revealed a ...

10-bromo-1,8-dihydroxy-9-anthrone (10-bromoanthralin) was synthesized with precise ratio of bromine to anthralin (1.10:1), respectively. With this ratio of the reagents, the reaction is repetitive at any scale. This compound is a highly significant intermediate for the synthesis of many anthralin derivetised antipsoriatic drugs. Bromination at both benzylic and aromatic ring positions of anthra...

A simple method for design of some novel 1,2-benzoxaphosphinines 2–9, was achieved. The methodology depended on cyclization 1-(2-hydroxy-phenyl)-3-phenylpropane-1,3-dione (1) as starting material with phosphorus halides in dry solvent the presence a base. Reaction substrate 1 halides, such P,P-dichlorophenylphosphine, phenyl phosphonic dichloride, phosphorodichloridate, and oxychloride toluene ...

The synthesis of 1,5-dihydroxy-9,10-anthraquinone (17); (1,5-DHA) was accomplished during, attempts towards the synthesis one of its derivatives called anthralin (1,8-dihydroxy-9-anthrone) which is known as an antipsoriasis drug since 1916 [1]. This work is a new reigiospecilic preparation of 1,5-DHA based on Friedel-Crafts reaction starting from 1,4-dimethoxybenzene. This synthetic route, ...

The characteristics of the skin tumor promotion response with anthrone derivatives has been further examined in SENCAR mice. Chrys arobin (l,8-dihydroxy-3-methyl-9-anthrone) was an effective skin tumor promoter when applied twice weekly with dose-dependent increases in both papillomas and squamous cell carcinomas between 25 and 100 nmol/ mouse. A similar dose-response relationship for papilloma...