Obesity has been related to subclinical inflammation and decreased levels of adiponectin. We examined the relationship between inflammatory markers and adiponectin and the change in body mass index (BMI) between childhood and adulthood. Our study included 368 subjects (176 men and 192 women) from a population-based cohort whose weight and height had been recorded at the age of seven years. They...

a series of angiotensin ii (a ii) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to qsar analysis using hansch and fujita-ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. several qsar model were obtained using stepwise regression analysis. two models from both the method...

objective: argemone mexicana is a papaveracea plant; some reports have shown their antibacterial, anti-cancer, sedative and probably anti-anxiety properties. from their aerial parts, flavonoids and alkaloids have been isolated, which are intrinsically related to some actions on the central nervous system. the aim of this study was to evaluate the anxiolytic-like effects of the plant, using its ...

introduction: we previously shown that microinjection of glutamate into the hdb of rat elicited cardiovascular depressive responses. microinjection of ap5 (an nmda receptor antagonist, 2.5 mm, 50 nl) and cnqx (an ampa receptor antagonist, 1 mm, 50 nl) caused no significant changes in the blood pressure and heart rate. microinjection of bicuculline (bmi: a gabaa receptor antagonist, 1 mm, 50 nl)...

Sigma-1 receptor (S1R) is an intracellular, multi-functional, ligand operated protein that also acts as a chaperone. It considered pluripotent drug target in several pathologies. The publication of agonist and antagonist bound structures has paved the way for receptor-based silico design. However, recent studies on this subject payed no attention to structural differences binding. In work, we h...

Adenosine A(1) receptor antagonists have diuretic/natriuretic activity and may be useful for treating sodium-retaining diseases, many of which are associated with increased renal sympathetic tone. Therefore, it is important to determine whether A(1) receptor antagonists alter renal sympathetic neurotransmission. In isolated, perfused rat kidneys, renal vasoconstriction induced by renal sympathe...

conclusions we observed acceptable results regarding both efficacy and safety with 62.5 mg of bosentan, twice daily in this group of patients. further clinical trials investigating pah with lower dosages of bosentan may be warranted. results no adverse drug reaction was observed during the follow-up. clinical worsening occurred in six (14%) patients, at least one year after treatment, two of th...

Objective(s): Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on inflammatory pain. The contribution of opiate receptors was explored using non-selective and selective antagonists. Materials and Methods: The fourth ventricle of the brain of anesthetized rats was impla...