نتایج جستجو برای: 1 transcripts igf

تعداد نتایج: 2789329  

Journal: :Molecular medicine reports 2015
Reem Amr Assal Hend Mohamed El Tayebi Karim Adel Hosny Gamal Esmat Ahmed Ihab Abdelaziz

MicroRNAs (miRs) have a major role in the pathogenesis of hepatocellular carcinoma (HCC). As the insulin-like growth factor (IGF) axis is a highly tumorigenic pathway in HCC, the present study attempted to target it with miRs. Potential targeting of crucial members of the IGF axis by miRNAs at the 3'-untranslated region (3'-UTR) was predicted using bioinformatic tools, such as microrna.org, Dia...

Journal: :Investigative ophthalmology & visual science 2006
Kay D A Beharry Houchang D Modanlou Jamal Hasan Zahra Gharraee Patricia Abad-Santos Jeremy H Sills Amanda Jan Stephen Nageotte Jacob V Aranda

PURPOSE Ibuprofen and indomethacin are nonselective prostaglandin synthetase inhibitors that have been shown to improve oxygen-induced retinopathy in mice. Vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF)-I, and growth hormone (GH) are potent growth factors involved in retinal development. This study was conducted to examine and compare the effects of early postnatal ...

Journal: :Journal of neurochemistry 1996
H L Cheng A Randolph D Yee P Delafontaine G Tennekoon E L Feldman

The insulin-like growth factors (IGFs) are trophic factors whose growth-promoting actions are mediated via the IGF-I receptor and modulated by six IGF binding proteins (IGFBPs). In this study, we observed increased transcripts of both IGF-I and IGF-I receptor after rat sciatic nerve transection. Schwann cells (SCs) were the main source of IGF-I and IGFBP-5 immunoreactivity until 7 days after ne...

Journal: :The Journal of veterinary medical science 1998
Y Yoshida M Miyamura S Hamano M Yoshida

We analyzed the expression of mRNAs for growth factor [epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF) and platelet-derived growth factor A chain (PDGF-A)] and their receptor (R) by reverse transcription-polymerase chain reaction in bovine ova during oocyte maturation in vitro (0-21 hr) and after fertilization in vitro (6-144 hr: zygote...

Journal: :Molecular pathology : MP 2001
W Zumkeller M Westphal

The insulin-like growth factor (IGF) system includes IGF-I and IGF-II, the type I and type II IGF receptors, and specific IGF binding proteins (IGFBP-1 to IGFBP-6). These factors regulate both normal and malignant brain growth. Enhanced expression of IGF-I and IGF-II mRNA transcripts has been demonstrated in gliomas, meniningiomas, and other tumours. Abnormal imprinting of IGF-II occurs in glio...

1999
THOMAS GUSTAFSSON PETER ANDERSSON YUN CHEN JAN OLOF MAGNUSSON HANS J. ARNQVIST Peter Andersson Yun Chen Jan Olof Magnusson

Gustafsson, Thomas, Peter Andersson, Yun Chen, Jan Olof Magnusson, and Hans J. Arnqvist. Interaction of angiotensin II and the insulin-like growth factor system in vascular smooth muscle cells. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H499–H507, 1999.—We studied the effects and interactions of ANG II and the insulin-like growth factor (IGF) system in cultured rat aortic smooth muscle cell...

2017
Xiaojuan Wan Songbo Wang Jingren Xu Lu Zhuang Kongping Xing Mengyuan Zhang Xiaotong Zhu Lina Wang Ping Gao Qianyun Xi Jiajie Sun Yongliang Zhang Tiejun Li Gang Shu Qingyan Jiang

Dietary protein or amino acid (AA) is a crucial nutritional factor to regulate hepatic insulin-like growth factor-1 (IGF-1) expression and secretion. However, the underlying intracellular mechanism by which dietary protein or AA induces IGF-1 expression remains unknown. We compared the IGF-1 gene expression and plasma IGF-1 level of pigs fed with normal crude protein (CP, 20%) and low-protein l...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2010
Eman M Gouda Gamal S Essawy

The insulin-like growth factor I (IGF-I) regulates growth, protein synthesis, and cell proliferation and differentiation in vertebrates. Polymorphisms of IGF-I gene transcripts of three breeds of chicken were assessed. The associations of these polymorphisms with the growth rate of the studied breeds were also evaluated. Total RNA was isolated from chicken livers, and the IGF-I gene was amplifi...

Journal: :In vivo 2008
A Philippou A Stavropoulou A Sourla N Pissimissis A Halapas M Maridaki M Koutsilieris

The human insulin-like growth factor-1 (IGF-1) gene gives rise to multiple, heterogeneous mRNA transcripts by alternative splicing, thus producing different IGF-1 isoforms. The mechano growth factor (MGF) is an IGF-1 isoform that was found to be markedly up-regulated in exercised or damaged muscle. The specific E domain of the MGF splice variant may act as an independent growth factor. The aim ...

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