It is, sometimes, desirable to maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an important area of pharmaceutical research and development. Of these systems, Pluronic F-127 (PF-127) provides ...

ions; urine test results; and HIV test results for 540 to more than 1,300 clients.

MicroRNAs (miRNAs) are small endogenous RNAs and are widely regarded as one of the most important regulators of gene expression in both plants and animals. To define the roles of miRNAs in fetal lung development, we profiled the miRNA expression pattern during lung development with a miRNA microarray. We identified 21 miRNAs that showed significant changes in expression during lung development....

The purpose of this study was to determine the expression of miR-127 and analyze its prognostic and biological significance in breast cancer (BC). A quantitative reverse transcription PCR assay was performed to detect the expression of miR-127 in 15 pairs of BC and corresponding noncancerous tissues. The expression of miR-127 was detected in another 110 BC tissues and its correlations with clin...

The challenge in developing oral drug delivery systems of poorly soluble basic drugs is primarily due to their pH dependent solubility. Cinnarizine (CNZ), a model for a poorly soluble basic drug, has pH dependent solubility; where it dissolves readily at low pH in the stomach and exhibits a very low solubility at pH values greater than 4. It is also characterized by a short half life of 3-6h, w...

The article begins by introducing specialized communication as the main domain of technical languages. It presents a brief survey of the development of the general theory Authenticated | [email protected] Download Date | 10/23/15 11:25 PM XIV. Word-formation and language use 2252 of terminology. Next, technical terms and their types, sources and definitions are discussed. Section 5 is dedicat...

Aim: Lymphocytic vasculitis is a morphological term which includes clinically heterogenous diseases like connective tissue disease, infection, lichenoid diseases, drug reaction, Behçet’s disease, superficial thrombophlebitis and leukemic vasculitis. There are three forms of lymphocytic vasculitis : angiodestructive form, lichenoid lymphocytic vasculitis and lymphocytic endovasculitis. There is ...

The intersection index at a common point of two analytic varieties of complementary dimensions in C is positive. This observation, which has been called a “cornerstone” of algebraic geometry ([GH, p. 62]), is a simple consequence of the fact that analytic varieties carry a natural orientation. Recast in terms of linking numbers, it is our principal motivation. It implies the following: Let M be...