The purpose of this Note is to prove a form of CLT (Theorem 1.4) that is used in Epstein and Seo (2011). More general central limit results and other applications will follow in later drafts. Let S = fB;Ng and K (S) = ffBg; fNg; fB;Ngg the set of nonempty subsets of S. Denote by s1 = (s1; s2; :::) the generic element of S1 and by n (s1) the empirical frequency of the outcome B in the …rst n exp...

BACKGROUND Iron deficiency and poor linear growth are common in infants from deprived socioeconomic backgrounds and may be associated with inadequate complementary feeding (CF) practices. OBJECTIVE We tested the hypothesis that new CF guidelines emphasizing meat as a source of iron and zinc would improve linear growth, iron, and zinc status in infants living in poor socioeconomic circumstance...

The proliferation of CRISPR/Cas9-based methods in Caenorhabditis elegans has enabled efficient genome editing and precise genomic tethering of Cas9 fusion proteins. Experimental designs using CRISPR/Cas9 are currently limited by the need for a protospacer adjacent motif (PAM) in the target with the sequence NGG. Here we report the characterization of two modified Cas9 proteins in C. elegans tha...

Southern Spain has the largest area of intensive greenhouse agriculture in Europe, and may constitute a special case of occupational and female exposure, because this type of farming requires considerable pesticide use and employs many women. We measured adipose tissue levels of 14 organochlorine pesticides in 458 women living in this area and analyzed the relationship between pesticide level/p...

This paper describes an eecient out-of-core algorithm for implicit time stepping schemes in one dimension. The algorithm can achieve a reduction in the amount of I/O over a conventional algorithm by a factor of maxf p M ; minfM;M 2 =ngg where M is the size of primary memory and n is the size of the state vector. We have implemented the algorithm and found it to be more than 5 times faster than ...

The reservoir for Neisseria meningitidis (Nm) is the human oropharynx. Implementation of Nm serogroup C (NmC) glycoconjugate vaccines directly reduced NmC carriage. Prophylactic vaccines are now available to prevent disease caused by the five major Nm disease causing serogroups (ABCWY). Nm serogroup B (NmB) vaccines are composed of antigens that are conserved across Nm serogroups and therefore ...

Due to worldwide restrictions on polybrominated diphenyl ethers (PBDEs), the demand for alternative flame retardants (AFRs), such as organophosphate flame retardants (OPFRs), novel brominated FRs (NBFRs) and hexabromocyclododecanes (HBCDs), has recently increased. Little is known about human exposure to NBFRs and OPFRs and that their levels in dust have been scarcely evaluated worldwide. To inc...

Access control techniques designed for single domain infrastructures, where users are known by domain administrators, provide considerable liberty in the usage of resources. This paradigm is not suitable for highly scalable and decentralised systems such as Grids and service oriented architectures (SOA), where resources are shared between domains, and users come from remote domains. One approac...

The type II CRISPR/Cas9 system has been used widely for genome editing in zebrafish. However, the requirement for the 5'-NGG-3' protospacer-adjacent motif (PAM) of Cas9 from Streptococcus pyogenes (SpCas9) limits its targeting sequences. Here, we report that a Cas9 ortholog from Staphylococcus aureus (SaCas9), and its KKH variant, successfully induced targeted mutagenesis with high frequency in...