TWO ROUTES FOR SYNTHESIS OF PHOSP~OENOLP~~ATE FROM C4-DICARBOXYLIC AICDS IN ESCHKRICHIA COLI Eric J. Hansen and Elliot Juni Department of Microbiology The University of Michigan Ann Arbor, Michigan 48104 Received June 28,1974 SUMMARY Mutants of s. coli defective in both phosphoenolpyruvate carboxykinase and phosphoenolpyruvate synthetase are unable to use C4-dicarboxylic acids such as suecinate...

A simple, robust, and sensitive high-performance liquid chromatography tandem mass spectrometry method was developed and validated for determination of a new nonpeptidic glucose-like peptide-1 receptor (GLP-1R) agonist 1,3-bis(4-((p-butoxycarbonyl)amino)benzamido)2,4-bis(m-methoxy-p-(thiophene-2-methanoyl)phenyl)cyclobutane-1,3-dicarboxylic acid (Boc5) in rat plasma using wogonin as internal st...

We compare the self-assembly of the various isomers of benzene-dicarboxylic acids at the interface between solution and graphite substrate. In the case of planar benzene-dicarboxylic acids it was possible to observe long-range ordered monolayers by STM. However, no ordered adsorption was observed for the nonplanar 1,2-benzene-dicarboxylic acid. By means of a control experiment with 1,2,4,5-benz...

The hydro-thermal reaction of benzene-1,4-dicarboxylic acid and 4,4'-trimethyl-ene dipiperidine leads to the formation of the title compound, C(13)H(28)N(2) (2+)·C(8)H(4)O(4) (2-). The anion is located on a center of inversion whereas the cation is positioned on a twofold rotation axis. In the crystal structure, the anions and cations are linked by N-H⋯O and N-H⋯(O,O) hydrogen bonds.

The proteolytic processing of the beta-amyloid precursor protein (APP) is regulated by neurotransmitters. Stimulation of metabotropic glutamate receptors (mGluRs) has been shown to increase the release of soluble amyloid precursor protein derivatives (APPs) from cultured cells. We examined the effects of mGluR agonists on APP processing in cortical and hippocampal slices from rat brain. Incubat...

Bacteria in anoxic environments typically convert aromatic compounds derived from pollutants or green plants to benzoyl-CoA, and then to the C7 dicarboxylic acid derivative 3-hydroxypimelyl-CoA. Inspection of the recently completed genome sequence of the purple nonsulfur phototroph Rhodopseudomonas palustris revealed one predicted cluster of genes for the beta-oxidation of dicarboxylic acids. T...

Several papers have already been published for answering the question whether or not the tricarboxylic acid cycle or the C4-dicarboxylic acid cycle plays a role in microorganisms, and a summarizing description of the subject is seen in Ajl's article(1). Karlson and Barker(2), for example, stated that the tricarboxylic acid cycle does not operate in Azotobacter agilis, Barron, Ardao and Hearon (...


 ABSTRACT. A novel series of mononuclear complexes the type, [M(L)(H2O)2] [M = Co(II) (1), Ni(II) (2), Zn(II) (3), Cd(II) (4), L dipicolinate), has been investigated using various techniques, including elemental analyses, FT-IR, 1H- and 13C NMR spectroscopy, powder XRD thermogravimetric analysis. The results indicate that coordination dipicolinic acid to metal ions involves two carboxylat...