نتایج جستجو برای: 1300 تا 1350
تعداد نتایج: 220381 فیلتر نتایج به سال:
Abstract. Interaction between peridotite and pyroxenite-derived melts can significantly modify the mineralogy chemistry of upper mantle, enhancing its heterogeneity, by creating re-fertilized peridotites secondary-type pyroxenites. We experimentally investigated reaction a fertile lherzolite MgO-rich basaltic andesite produced partial melting an olivine-free pyroxenite at 2 GPa 1300–1450 ∘C. Th...
In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI (functional magnetic resonance imaging), we show that healthy older adults demonstrated a prominent deficit in the suppression of cortical activity asso...
Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these d...
Brain metastases are a major cause of mortality in patients with advanced melanoma. Adequate brain distribution of targeted agents for melanoma will be critical for treatment success. Recently, improvement in overall survival led to US Food and Drug Administration (FDA) approval of the v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, vemurafenib and dabrafenib, and the mitogenac...
PURPOSE To document incidence of and risk factors for development of retinopathy of prematurity (ROP) in a population of low birthweight infants (< 1500 g). METHODS The authors registered clinical characteristics (birthweight, gestational age (GA), Clinical Risk Index for Babies (CRIB), Apgar score, respiratory characteristics (intubation, ventilation, respiratory support, supplemental oxygen...
In this article we shall present an overview of the development of calculus in Indian mathematical tradition. The article is divided naturally into two parts. In the first part we shall discuss the developments during what may be called the classical period, starting with the work of Āryabhat.a (c. 499 CE) and extending up to the work Nārāyan. a Pan.d. ita (c. 1350). The work of the Kerala Scho...
Acrolein is an electrophilic a,b-unsaturated aldehyde of industrial, pharmaceutic, and toxicologic importance to which we are exposed in environmental, occupational, and therapeutic situations. Acrolein is known to exert different biologic effects through reactions with cellular macromolecules such as DNA, certain proteins, or glutathione. In many situations (such as in tobacco smoke or other f...
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