The analysis of the 3D model structure of the ternary complex of recombinant formate dehydrogenase from soya Glycine max (EC 1.2.1.2., SoyFDH) with bound NAD+ and an inhibitor azide ion revealed the presence of hydrophobic Phe290 in the coenzyme-binding domain. This residue should shield the enzyme active site from solvent. On the basis of the alignment of plant FDHs sequences, Asp, Asn and Ser...

Описаний клінічний випадок 12-річної дитини з остеосаркомою лівої малогомілкової кістки, Т1N0M0G3, яка отримувала лікування високодозовим метотрексатом 12 г/м2. Внаслідок затримки елімінації метотрексату в дівчинки розвинулась гостра печінкова недостатність. У пацієнтки рівень АЛТ підвищувався до 4790 Од/л, АСТ — 4320 що свідчить про загрозливе для життя гостре ураження печінки. При цьому не ві...

Micro-electro-mechanical Systems (MEMS) are components with micron-scale moving parts based on materials and processes of microelectronics fabrication. This is a good example of on-chip integration of electronics, microstructures, microsensors and microactuators. Accurate simulation of MEMS requires precise modeling of all effects of mechanical and damping forces, electrostatic forces and inner...

Context. While [O iii] narrow-band imaging is commonly used to measure the size of the narrow-line regions (NLRs) in active galactic nuclei (AGNs), it can be contaminated by emission from surrounding starbursts. Recently, we have shown that long-slit spectroscopy provides a valuable alternative approach to probe the size in terms of AGN photoionisation. Moreover, several parameters of the NLR c...

Schaller on Archer ............................. 1379 Coruell on Archer .............................. 1380 Eagly on Archer ................................. 1380 Archer Replies ................................... 1383 Hojat on the U.N. Convention on the Rights of the Child ................ 1384 Wessells on the U.N. Convention on the Rights of the Child ............... 1385 Juni on Students' Ri...