Diabetic foot ulcers (DFUs) are a devastating complication of diabetes; one in four diabetics will develop non-healing chronic ulcer, which potentially leads to lower limb amputations. This globally escalating medical issue lacks approved pharmacologic options. We identified defective molecular switch DFUs; consequence dysregulated TGF-b signaling. The deleterious effect failure this is apparen...

*Department of Zoology, Box 7617, North Carolina State University, Raleigh, NC 27695–7617, U.S.A., email nick [email protected] †Oregon Cooperative Fish and Wildlife Research Unit, Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97333, U.S.A., email [email protected] ‡Department of Fisheries and Wildlife Biology, Colorado State University, Fort Collins, CO 80523–...

The regulation of gene transcription involves a dynamic balance between packaging regulatory sequences into chromatin and allowing transcriptional regulators access to these sequences. Access is restricted by the nucleosomes, but these can be repositioned or ejected by enzymes known as nucleosome remodellers. In addition, the DNA sequence can impart stiffness or curvature to the DNA, thereby af...

1474-0346/$ see front matter 2009 Elsevier Ltd. A doi:10.1016/j.aei.2009.08.007 q This work is partially supported by Grants from t (2005-3642, 2005-4050), the Swedish Aeronautics S4203), the SSF Strategic Research Center MOVIII, th Linnaeus Center CADICS, and the Center for Indust CENIIT (06.09). * Corresponding author. Tel.: +46 7