Although studies have evaluated the ecotoxicity and fate of trenbolone acetate (TBA) metabolites, namely 17α-trenbolone (17α-TBOH), 17β-trenbolone (17β-TBOH), and trendione (TBO), their environmental transport processes remain poorly characterized with little information available to guide agricultural runoff management. Therefore, we evaluated TBA metabolite transport in representative agricul...

Cichlids offer an exciting opportunity to understand vertebrate speciation; chemical communication could be one of the drivers of African cichlid radiation. Chemical signals mediate key aspects in the lives of vertebrates and often are species specific. Dominant male Mozambique tilapia [Oreochromis mossambicus (Peters 1852)] release a sex pheromone, 5β-pregnan-3α,17α,20β-triol 3-glucuronate and...

Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. As such, it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. Biotransformation of ...

Anabolic androgenic steroids (AAS), synthetic testosterone derivatives that are used for ergogenic purposes, alter neurotransmission and behaviors mediated by GABA(A) receptors. Some of these effects may reflect direct and rapid action of these synthetic steroids at the receptor. The ability of other natural allosteric steroid modulators to alter GABA(A) receptor-mediated currents is dependent ...

Article history: Received on: 28/11/2012 Revised on: 17/12/2012 Accepted on: 24/12/2012 Available online: 29/12/2012 The effects of different anti-estrogenic chemicals were evaluated in guppy, Poecilia reticulata on sex differentiation and survival. New-born fry of the fish were fed diets containing genistein (1 gm kg), tamoxifen (100 mg kg), methanol extract of Basella alba (1 gm kg) and 17α-m...

Environmental Protection includes programs that are aimed to reducing risks the environment from hazardous materials and chemical wastes. Nowadays, 17α-ethinylestradiol, a synthetic estrogen, has become one of most commonly used active ingredients for oral contraception, interfere with normal functioning endocrine systems, thus affecting reproduction development in wildlife. The fresh water foo...

This study aimed to develop sex reversal procedures targeting the embryonic period as tools to study the early steps of sex differentiation in Nile tilapia with XX, XY, and YY sexual genotypes. XX eggs were exposed to masculinizing treatments with androgens (17α-methyltestosterone, 11-ketotestosterone) or aromatase inhibitor (Fadrozole), whereas XY and YY eggs were subjected to feminizing treat...