The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 4 541–557 www.jcb.org/cgi/doi/10.1083/jcb.201307050 JCB 541 Correspondence to Taras Y. Nazarko: [email protected]; or Suresh Subramani: [email protected] Abbreviations used in this paper: 30BS, Atg30 binding site; ACBD5, acylCoA–binding domain containing protein 5; ACBS, acyl-CoA binding site; AD, Alzheimer’s disease; AIM, Atg...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 1 53–69 www.jcb.org/cgi/doi/10.1083/jcb.201404109 JCB 53 Correspondence to Rabindranath De La Fuente: [email protected]; or John C. Schimenti: [email protected] Abbreviations used in this paper: ACT, activator of CREM in testis; CREM, cAMP response element modulator; GV, germinal vesicle; IAP, intracisternal A particle; MGI, Mouse...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 4 475–491 www.jcb.org/cgi/doi/10.1083/jcb.201406121 JCB 475 *W.A. Comrie and A. Babich contributed equally to this paper. Correspondence to Janis K. Burkhardt: [email protected] Abbreviations used in this paper: APC, antigen-presenting cell; Bleb, blebbistatin; cSMAC, central supramolecular activation cluster; dSMAC, d...

Multiple system atrophy is a sporadic alpha-synucleinopathy that typically affects patients in their sixth decade of life and beyond. The defining clinical features of the disease include progressive autonomic failure, parkinsonism, and cerebellar ataxia leading to significant disability. Pathologically, multiple system atrophy is characterized by glial cytoplasmic inclusions containing filamen...

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations were identified they were postulated to give rise to amyotrophic lateral sclerosis through a loss of function mechanism, but experimental data soon showed that the disease arises from a—still unknown—toxic gain of func...

Improving neurological outcome after spinal cord injury is a major clinical challenge because axons, once severed, do not regenerate but ‘dieback’ from the lesion site. Although microglia, the immunocompetent cells of the brain and spinal cord respond rapidly to spinal cord injury, their role in subsequent injury or repair remains unclear. To assess the role of microglia in spinal cord white ma...

1 Department of Neuroimmunology, Centre for Brain Research, Medical University of Vienna, Austria 2 Institute of Neurology, Medical University of Vienna, Austria 3 The Mitochondrial Research Group, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK 4 Research Centre for Molecular Medicine (CeMM) of the Austrian Academy of Sciences and Depa...

1 Instituto de Neurociencias de Alicante UMH-CSIC, San Juan de Alicante 03550, Spain 2 Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Hospital General Universitario de Alicante, Alicante 03010, Spain 3 Institut de Medicina Predictiva i Personalitzada del Càncer (IMPPC), Barcelona 08916, Spain 4 Grupo Supresión Tumoral, Centro Nacional d...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 3 313–329 www.jcb.org/cgi/doi/10.1083/jcb.201403111 JCB 313 *C. Colombelli and M. Palmisano contributed equally to this paper. Correspondence to M.L. Feltri: [email protected] Abbreviations used in this paper: CNS, central nervous system; DG, Dystroglycan; DRG, dorsal root ganglia; ERM, ezrin/radixin/moesin; HS, heparan sulfa...

What is the relation between the material, conventional symbol structures that we encounter in the spoken and written word, and human thought? A common assumption, that structures a wide variety of otherwise competing views, is that the way in which 10 these material, conventional symbol-structures do their work is by being translated into some kind of content-matching inner code. One alternati...