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Purpose: Although the majority of patients with HPVþ oropharyngeal cancers have a favorable prognosis, there are some patients with tumors that are resistant to aggressive chemoradiotherapy with unusual patterns of locoregional and systemic recurrences. Therefore, more effective therapies are needed. In this study, we investigated the chemosensitizing efficacy of the selective Wee-1 kinase inhi...

Abstract Introduction Obstructive sleep apnea (OSA) and type 2 diabetes (T2Dia) is a frequent clinical association. Beyond OSA-related hypoxic burden, increased respiratory effort (RE) one of the main features OSA contributes to sympathetic overactivity that in turn might participate glucose homeostasis dysregulation. The independent contribution RE OSA-T2Dia pathogenesis remains be demonstrate...

This issue of the McGill Journal of Medicine marks something of an anniversary for the Journal, and before commenting on the articles in this issue, we thought this a fitting time for reflection on the state of the MJM. Though we chart our recent history through a period of beginning, ending, and beginning and ending again, we have embarked with conviction on the course which was once set for t...

PURPOSE The purpose of this study was to verify the clinical-feasibility of additive manufacturing by comparing the accuracy of four different manufacturing methods for metal coping: the conventional lost wax technique (CLWT); subtractive methods with wax blank milling (WBM); and two additive methods, multi jet modeling (MJM), and micro-stereolithography (Micro-SLA). MATERIALS AND METHODS Thi...

Although cisplatin has played a role in "standard-of-care" multimodality therapy for patients with advanced squamous cell carcinoma of the head and neck (HNSCC), the rate of treatment failure remains particularly high for patients receiving cisplatin whose tumors have mutations in the TP53 gene. We found that cisplatin treatment of HNSCC cells with mutant TP53 leads to arrest of cells in the G2...

Steno's inability to explain an affair of the soul such as pain in terms of the impact of matter reveals the dualist split between science and religion which makes itself increasingly perceptible at the time and seems to have troubled him fundamentally. Had earlier scientific men such as Harvey and Van Helmont been perhaps happier in their monist view of the world and of the 'working-matter' in...

PURPOSE To identify novel therapeutic drug targets for p53-mutant head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN RNAi kinome viability screens were performed on HNSCC cells, including autologous pairs from primary tumor and recurrent/metastatic lesions, and in parallel on murine squamous cell carcinoma (MSCC) cells derived from tumors of inbred mice bearing germline mutati...

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, in part, because of the lack of effective targeted therapeutic options. MK-1775 (also known as AZD1775), a mitotic inhibitor, has been demonstrated to enhance the anti-tumor effects of DNA damaging agents such as gemcitabine. We evaluated the efficacy of MK-1775 alone or in combination with DNA damaging agents (MMC or oxaliplatin) in P...