نتایج جستجو برای: 184 susceptible
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PURPOSE A mutation miR-184(+57C>T) in the seed region of miR-184 (encoded by MIR184 [MIM*613146]) results in familial severe keratoconus combined with early-onset anterior polar cataract and endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning (EDICT) syndrome (MIM#614303). In order to investigate the phenotypic spectrum resulting from MIR184 mutation, MIR184 was se...
BACKGROUND Early metastasis of osteosarcoma (OS) is highly lethal and responds poorly to drug and radiation therapies. MicroRNAs (miRNAs) are a class of small noncoding RNAs that modulate gene expression at the post-transcriptional level. However, the detailed functions of specific miRNAs are not entirely understood. The aim of the present study was to investigate the role of miR-184 as a media...
It is commonly alleged that a substantial proportion of lawsuits are frivolous and are filed only for their nuisance value. This paper models settlement bargaining in the presence of frivolous suits as a game of asymmetric information, where the plaintiff knows the true merits of his claim, and the defendant does not, apart from any inferences he can draw from the fact of suit. When there is fr...
Kojima and Manea (2010) present two characterizations of when an allocation rule corresponds to the agent-proposing deferred acceptance algorithm for some substitutable priority rule of the objects being assigned. Building on their results we characterize when an allocation rule is outcome equivalent to the deferred acceptance algorithm for every substitutable priority rule. In particular, an a...
This paper describes an approach for the identification of flood-susceptible areas contributing to sustainability these in Giofiros river basin covering area 184 km2, located Southern Greece. is prone flooding with devastating consequences on people, environment, and economy. In this context, a geographic information system (GIS)–based multi-criteria decision analysis (MCDA) method potential fl...
miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related function in vivo remained unclear. Here, we report that the miR-184 knockout mouse model displayed increased p63 expression in line with epidermal hyperplasia,...
Thin layers of gels with mechanical properties mimicking animal tissues are widely used to study the rigidity sensing of adherent animal cells and to measure forces applied by cells to their substrate with traction force microscopy. The gels are usually based on polyacrylamide and their elastic modulus is measured with an atomic force microscope (AFM). Here we present a simple microfluidic devi...
m-miR-184 (mutant miR-184, r.57c > u) appears in familial hereditary ocular diseases, including keratoconus, cataracts, EDICT (endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning) syndrome, severe keratoconus, and non-ectatic corneal thinning. The biological function of m-miR-184 in these ocular diseases remains unclear. With the emergence of high-throughput sequen...
Abstract Fraud in public funding can have deleterious consequences for societies’ economic, social, and political well-being. Fraudulent activity associated with procurement contracts accounts losses of billions euros every year. Thus, it is utmost relevance to explore analytical frameworks that help authorities identify agents are more susceptible irregular activities. Here, we use standard ne...
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