6.2 DIMETHYL SULFOXIDE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1 Action of DMSO on SW620 cells in culture . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1.1 Growth rate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 6.2.1.2 Morphology . . . . . . . . . . . . . . . . . . . ...

The notion of Steiner visibility graphs is introduced. Their applicability in connection with the construction of good quality suboptimal solutions to the Euclidean Steiner tree problem with obstacles is discussed. Polynomial algorithms generating Steiner visibility graphs are described.

Perceived trustworthiness is a critical antecedent of interpersonal trust, yet researchers have a limited understanding of how such perceptions are generated. The authors used 2 competing perspectives within the relational demography literature— similarity–attraction and relational norms—to empirically examine the effect of demographic differences. Whereas the similarity–attraction account sugg...

Accumulating evidence is emerging that microRNAs (miRNAs) are key regulators in controlling neuroinflammatory responses that are known to play a potential role in the pathogenesis of temporal lobe epilepsy (TLE). The aim of the present study was to investigate the dynamic expression pattern of interleukin (IL)-10 as an anti-inflammatory cytokine and miR-187 as a post-transcriptional inflammatio...

We investigated the bulk electrical conductivity and microbial population distribution in sediments at a site contaminated with light nonaqueous-phase liquid (LNAPL). The bulk conductivity was measured using in-situ vertical resistivity probes; the most probable num­ ber method was used to characterize the spatial distri­ bution of aerobic heterotrophic and oil-degrading mi­ crobial populations...

We have analyzed the topological organization of chromatin inside mitotic chromosomes. We show that mitotic chromatin is heavily self-entangled through experiments in which topoisomerase (topo) II is observed to reduce mitotic chromosome elastic stiffness. Single chromosomes were relaxed by 35% by exogenously added topo II in a manner that depends on hydrolysable adenosine triphosphate (ATP), w...

Studies were made of the influence of ICRF-187 on the functional and morphological effects of very large cumulative doses of doxorubicin given over a prolonged period of time. Adult beagles of either sex (6.2-11.6 kg) were given doxorubicin (1.75 mg/kg i.v.) either alone or 15 min after ICRF-187 (25 mg/kg, i.v.) at 3-week intervals. Control dogs received ICRF-187 (25 mg/kg, i.v.) or 0.9% saline...

The cyclotron frequency ratio of $^{187}\mathrm{Os}^{29+}$ to $^{187}\mathrm{Re}^{29+}$ ions was measured with the Penning-trap mass spectrometer PENTATRAP. achieved result $R=1.000\:000\:013\:882(5)$ is date most precise such measurement performed on ions. Furthermore, total binding-energy difference 29 missing electrons in Re and Os calculated by relativistic multiconfiguration methods, yield...

Dexrazoxane (ICRF-187) is a catalytic inhibitor of the nuclear enzyme DNA topoisomerase II (topo II). It protects cells against topo II poisons, such as etoposide and teniposide, by hindering the DNA cleavage reaction of the target enzyme. We have previously shown that this antagonism also extends to an in vivo model. Thus, ICRF-187 protected mice against supralethal doses of etoposide and amsa...

The tSNARE (the target-membrane soluble NSF-attachment protein receptor, where NSF is N -ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25 kDa (SNAP-25) is implicated in regulated insulin secretion. In pheochromocytoma PC12 cells, SNAP-25 is phosphorylated at Ser(187), which lies in a region that is important for its function. The aims of the present study were to d...