AIM To assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging (1H-MRSI) and glycolysis as observed on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in prostate cancer (PCa) patients. METHODS The study included 22 patients with local PCa who were re...

Kanker prostat merupakan kanker tersering kedua dan menjadi penyebab kematian kedelapan akibat pada laki-laki di dunia; Indonesia, kejadian berada urutan kelima sebesar 7,4% dari 183.368 kasus baru. Modalitas pencitraan struktural (USG, CT, MRI) pemeriksaan standar klinis sehari-hari, tetapi terbatas untuk staging prostat, restaging pasien dengan kekambuhan biokimia, serta menilai respons terap...

Glioblastoma (GB) is a highly heterogeneous tumor. In order to identify in vivo the most malignant tumor areas, the extent of tumor infiltration and the sites giving origin to GB stem cells (GSCs), we combined positron emission tomography/computed tomography (PET/CT) and conventional and advanced magnetic resonance imaging (MRI) with histology, immunohistochemistry and molecular genetics. Prior...

OBJECTIVE Glioma heterogeneity and the limitations of conventional structural MRI for identifying aggressive tumor components can limit the reliability of stereotactic biopsy and, hence, tumor characterization, which is a hurdle for developing and selecting effective treatment strategies. In vivo MR spectroscopy (MRS) and PET enable noninvasive imaging of cellular metabolism relevant to prolife...

BACKGROUND To evaluate and compare the utility of 18F-fluorocholine (18F-CH) PET/CT versus 3-Tesla multiparametric MRI (mpMRI) without endorectal coil to detect tumor recurrences in patients with biochemical relapse following radical prostatectomy (RP). Secondarily, to identify possible prognostic variables associated with mpMRI and 18F-CH PET/CT findings. METHODS Retrospective study of 38 pa...

can be used for imaging trabecular changes caused by the metastasis, however, those changes appear relatively late in the course of bone metastases. Therefore, a challenge for imaging prostate cancer is to increase the diagnostic performance. Functional and molecular imaging technologies, such as PET, compared with conventional imaging, offer the possibility to image tumor-specific processes. C...

Purpose Hypoxia is a major factor in prostate cancer aggressiveness and radioresistance. Predicting which patients might be bad candidates for radiotherapy may help better personalize treatment decisions in intermediate-risk prostate cancer patients. We assessed spatial distribution of 18F-Misonidazole (FMISO) PET/CT uptake in the prostate prior to radiotherapy treatment. Materials and Method...

PURPOSE To characterize intermediate and high-risk prostate carcinomas with measurements of standardized uptake values (SUVs) and apparent diffusion coefficient (ADC) values by means of simultaneous [18F] choline PET/MRI. MATERIALS AND METHODS 35 patients with primary prostate cancer underwent simultaneous [18F] choline PET/MRI. From these, 21 patients with an intermediate and high risk const...