Non-alcoholic fatty liver disease (NAFLD) encompasses the often benign non-alcoholic fatty liver (NAFL) characterized by hepatic steatosis with or without mild inflammation and the more complicated non-alcoholic steatohepatitis (NASH) with lobular inflammation and hepatocellular ballooning which can be complicated by fibrosis. Independent associates for the presence of liver fibrosis in patient...

To the Editor: In the 1st issue of HJNM for 2012 we read with interest a case where 3 different cancers were detected [1]. Synchronous second malignancy can be incidentally detected in routine fluorine-18-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/ CT) imaging in approximately 1% of cancer patients with lungs being the most frequent site [2]. We report th...

My interest in imaging breast cancer with PET began in the late 1980s with my, and many others’, gradual recognition that the radiotracer 18F-FDG, originally designed for brain imaging, was actually a promising visceral tumor imaging agent (1–3). The early contributions of the late Ludwig Strauss to colorectal cancer imaging with PETwere quite informative at that time (4). Although at that stag...

Cancer is a genetic disease. Mutated oncogenes and tumor suppressor proteins activate signaling networks that underlie many of the characteristic hallmarks of cancer. Cancer is also a metabolic disease. Long before the identification of oncogenes, Otto Warburg showed that cancer cells consume large amounts of glucose relative to normal cells, forming the basis for 18FFDG PET imaging. Instead of...

With an incidence of 20.5 per 100,000 people each year, tumors of the central nervous system are a heterogeneous group, with meningiomas (35.5%) and gliomas (30%) being the most common (1). Although 97% of meningiomas are benign, 54% of gliomas are highly malignant glioblastomas of World Health Organization (WHO) grade IV. Survival rates are 35.7% at 1 y and 4%–7% at 5 y for glioblastoma, 60%–8...