1. Excitation-contraction coupling is broadly defined as the process linking the action potential to contraction in striated muscle or, more narrowly, as the process coupling surface membrane depolarization to Ca(2+) release from the sarcoplasmic reticulum. 2. We now know that excitation-contraction coupling depends on a macromolecular protein complex or 'calcium release unit'. The complex exte...

Autonomous Lagrangian Circulation Explorer floats recorded temperatures in depths between 700 and 1100 meters in the Southern Ocean throughout the 1990s. These temperature records are systematically warmer than earlier hydrographic temperature measurements from the region, suggesting that mid-depth Southern Ocean temperatures have risen 0.17 degrees C between the 1950s and the 1980s. This warmi...

PURPOSE To estimate the doses to the heart and coronary arteries from common breast cancer radiotherapy (RT) regimens used worldwide from the 1950s to the 1990s. METHODS AND MATERIALS Virtual simulation and computed tomography planning were used to reconstruct the megavoltage and electron regimens. Manual planning was used for the orthovoltage and brachytherapy regimens. Several sources of va...

and involvement of the trabecular meshwork for 270 degrees. The visual acuity was “normal OU”. Initial treatment consisted of a multitier approach using intra-arterial, intravitreal, and intracameral melphalan. This was followed by 4 monthly cycles of neoadjuvant systemic carboplatin and etoposide. An anterior chamber recurrence was noted 3.5 months later and further intracameral and intravitre...