After years of effort, investigators at Vanderbilt and Columbia found the gene for heritable pulmonary hypertension (PH) nearly simultaneously in the year 2000. Mutations in the so-called bone morphogenetic protein receptor type 2 (BMPR2) are now known to be responsible for about 75% of cases of heritable pulmonary arterial hypertension (PAH). In the other 25% of families, either the mutation r...

A volume such as the one considered here is different from many of the "Reviews" books available today: (1) it is sponsored by two major scientific societies, The Society for Epidemiologic Research and the International Epidemiological Association; and (2) it is published under the editorial management of a major journal, the American Journal ofEpidemiology. We expect such a volume to be well e...

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