BACKGROUND The extracellular matrix is a dynamic and complex network of macromolecules responsible for maintaining and influencing cellular functions of the airway. The role of fibronectin, an extracellular matrix protein, is well documented in asthma. However, the expression and function of fibulin-1, a secreted glycoprotein which interacts with fibronectin, has not been reported. Fibulin-1 is...

A new scaffold, azolylthioacetamide, was constructed and assayed against metallo-β-lactamases (MβLs). The obtained molecules specifically inhibited MβL ImiS, and 1c was found to be the most potent inhibitor, with a K i = 1.2 μM using imipenem as substrate. Structure-activity relationships reveal that the aromatic carboxyl improves inhibitory activity of the inhibitors, but the aliphatic carboxy...

coenzyme q 10 is a natural antioxidant and free radicals scavenger. in the present study, we examined effect of coenzyme q 10 on hemoglobin a 1c , serum urea and creatinine in alloxan-induced type 1 diabetic rats. thirty sprage-dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme q 10 (15 mg/kg i...

where μ1 = 0.3, μ2 = 0.9, σ1 = 0.1, σ2 = 0.2 and c = 0.3. In Fig. 1D we used a prior pS(θ) = pS(θ1)pS(θ2), with pS(θi) given by a normal distribution (μ = 0.3, σ = 0.35). A learning rate of η = 0.005 was used to sampled trajectories which had a length of 50 and 300 time steps in Fig. 1C and F, respectively. In Fig. 1F the time-discrete version of the synaptic sampling algorithm (7) was used, wi...

This paper proposes new explicit formulae for the point doubling, tripling and addition on ordinary Weierstrass elliptic curves with a point of order 3 over finite fields of characteristic three. The cost of basic point operations is lower than that of all previously proposed ones. The new doubling, mixed addition and tripling formulae in projective coordinates require 3M + 2C, 8M + 1C + 1D and...

This paper presents new explicit formulae for the point doubling, tripling and addition for ordinary Weierstraß elliptic curves with a point of order 3 and their equivalent Hessian curves over finite fields of characteristic three. The cost of basic point operations is lower than that of all previously proposed ones. The new doubling, mixed addition and tripling formulae in projective coordinat...

A 29-year old man presented with chronic cough. A chest X-ray revealed several faint round opacities in the right upper zone (Fig. 1a). Computed tomography showed a mass occluding the right main pulmonary artery (Fig. 1b). Positron emission tomography showed increased activity (Fig. 1c). He underwent median sternotomy and intrapericardial right pneumonectomy. Histopathology revealed an intravas...

3.1: Treatment of the initial episode of SSNS 3.1.1: We recommend that corticosteroid therapy (prednisone or prednisolone)* be given for at least 12 weeks. (1B) 3.1.1.1: We recommend that oral prednisone be administered as a single daily dose (1B) starting at 60 mg/m/d or 2 mg/kg/d to a maximum 60 mg/d. (1D) 3.1.1.2: We recommend that daily oral prednisone be given for 4–6 weeks (1C) followed b...

A 26-year-old man suffered a severe impact in a car crash. Computed tomography showed an image suspicious for coronary injury (Fig. 1a). Coronary angiography (Fig. 1b, Supplementary Video 1) revealed a pseudoaneurysm of the first diagonal branch. Sealing was cancelled because of spontaneous healing (Fig. 1c, Supplementary Video 2). Pseudoaneurysm disappeared and coronary artery remained normal ...

A new type of dioxetane bearing a 3-(cyanomethyl)phenyl (1a), 3-(methoxycarbonylmethyl)phenyl (1b), 3-(benzoylmethyl)phenyl (1c), or 3-[cyano(methoxycarbonyl)methyl]phenyl group (1d) decomposed through an intermediary dioxetane bearing a benzylic carbanion to afford crimson to yellow light on treatment with TBAF in DMSO.